Article citationsMore>>
Chaouni, B.A., Galtier, C., Allouchi, H., Kherbeche, A., Chavignon, O., Teulade, J.C., Witvrouw, M., Pannecouque, C., Snoeck, R., Andrei, G., Balzarini, J., De Clercq, E., Fauvelle, F., Enguehard, C. and Gueiffier, A. (2001) 3-Benzamido, Ureido and Thioureidimidazo[1,2-a]Pyridine Derivatives as Potential Antiviral Agents. Chemical and Pharmaceutical Bulletin, 49, 1631-1635.
http://dx.doi.org/10.1248/cpb.49.1631
has been cited by the following article:
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TITLE:
Synthesis of Novel Fluorine Substituted Isolated and Fused Heterobicyclic Nitrogen Systems Bearing 6-(2’-Phosphorylanilido)-1,2,4-Triazin-5-One Moiety as Potential Inhibitor towards HIV-1 Activity
AUTHORS:
Reda M. Abdel-Rahman, Mohammed S. T. Makki, Abeer N. Al-Romaizan
KEYWORDS:
Synthesis, Fluorine, Phosphorus, Sulfar 1, 2, 4-Trizinones HIV-1
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.4 No.4,
December
16,
2014
ABSTRACT: Novel 6-(5’-fluoro-2’-diphenylphosphorylanilido)-3-hydrazino-1,2,4-trizin-5 (2H) one (3) is achieved from hydrozinolysis of the corresponding 3-thioxo-analoges 2. Compound 2 is also obtained from phosphorylation of 6-(5’-fluoro-2’-aminophenyl)-3-thioxo-1,2,4-triazin-5(2H) one (1). Novel fluorine substituted isolated and/or fused heterobicyclic nitrogen systems bearing and/or containing, 6-phosphoryl anilido-1,2,4-trizin-5 (2H) one moiety (4 - 22) have been synthesized from ring closure reactions of compound 3 with π-acceptors activated carbon compounds in different medium and conditions. Structures of the products are characterized by MS, IR, UV-VIS, CH, N, and 1H/13CNMR spectral data. The new products have been evaluated as potential inhibitors towards HIV-1 activity.