Abdel-Rahman, R.M. (1988) Reactions of 3-Hydrazino-5,6-diphenyl-1,2,4-triazine with Unsymmetrical 1,3-bicarbonyl Compounds: Synthesis of Some New 3-(3’,5’-Disubstituted pyrazol-1’-yl(-5-6-diphenyl-1,2,4-triazines of Their Antimicrobial Activity. Indian Journal of Chemistry, 27B, 548-553.

has been cited by the following article:

• TITLE: Synthesis of Novel Fluorine Substituted Isolated and Fused Heterobicyclic Nitrogen Systems Bearing 6-(2’-Phosphorylanilido)-1,2,4-Triazin-5-One Moiety as Potential Inhibitor towards HIV-1 Activity

  AUTHORS: Reda M. Abdel-Rahman, Mohammed S. T. Makki, Abeer N. Al-Romaizan

  KEYWORDS: Synthesis, Fluorine, Phosphorus, Sulfar 1, 2, 4-Trizinones HIV-1

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.4 No.4, December 16, 2014

  ABSTRACT: Novel 6-(5’-fluoro-2’-diphenylphosphorylanilido)-3-hydrazino-1,2,4-trizin-5 (2H) one (3) is achieved from hydrozinolysis of the corresponding 3-thioxo-analoges 2. Compound 2 is also obtained from phosphorylation of 6-(5’-fluoro-2’-aminophenyl)-3-thioxo-1,2,4-triazin-5(2H) one (1). Novel fluorine substituted isolated and/or fused heterobicyclic nitrogen systems bearing and/or containing, 6-phosphoryl anilido-1,2,4-trizin-5 (2H) one moiety (4 - 22) have been synthesized from ring closure reactions of compound 3 with π-acceptors activated carbon compounds in different medium and conditions. Structures of the products are characterized by MS, IR, UV-VIS, CH, N, and 1H/13CNMR spectral data. The new products have been evaluated as potential inhibitors towards HIV-1 activity.