Chitsike, R.S., Rodger, M.A., Kovacs, M.J., Betancourt, M.T., Wells, P.S., Anderson, D.R., Chagnon, I., Le Gal, G., Solymoss, S., Crowther, M.A., Perrier, A., White, R.H., Vickars, L.M., Ramsay, T. and Kahn, S.R. (2012) Risk of Post-Thrombotic Syndrome after Subtherapeutic Warfarin Anticoagulation for a First Unprovoked Deep Vein Thrombosis: Results from the REVERSE Study. Journal of Thrombosis and Haemostasis, 10, 2039-2044.
http://dx.doi.org/10.1111/j.1538-7836.2012.04872.x

has been cited by the following article:

• TITLE: Elderly Disabled Patients in Oral Anticoagulation Treatment: An Evaluation of a Bioanalyst-Led Management Program Reaching an Average of 72% of Time in Therapeutic Range

  AUTHORS: Thomas Vedtofte, Gitte Vedel Melsen, Lise Bathum, Christina Ellervik, Maja Jørgensen

  KEYWORDS: Warfarin, INR, Time in Therapeutic Range, Elderly, Nursery Care Setting

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.4 No.12, November 28, 2014

  ABSTRACT: Introduction: The need for anticoagulation therapy increases with age, mainly due to the increased prevalence of atrial fibrillation. Time in therapeutic range (TTR) is a marker of the quality of the therapy as TTR is inversely correlated with adverse reactions. We developed a bioanalyst-led management program for control of warfarin treatment in elderly disabled patients in their own home and maintain a high TTR. Material and Methods: Residents in nursing home settings were included. Visiting nurses measured INR with a point of care testing device. If INR was within Therapeutic Range (TR), the nurse dosed warfarin unaltered. If INR was out of TR, the visiting nurse contacted a specially trained bioanalyst by phone. An explanation was sought, and a new dosage plan was made. Results: A total of 579 patients were included; 356 females (61%). Mean age was 79.6 years. Approximately 10% were residents in nursing home settings and the rest in domiciliary care. TTR was 72%. The subtherapeutic values were 15% and supratherapeutic values 13%. In total, 139 patients died during the study period. Ten deaths could be related to possible side effects of warfarin treatment. Conclusions: Our results indicate that a bioanalyst-led program is able to simplify anticoagulation monitoring, while maintaining INR control similar to a specialized clinic. Furthermore, we avoided hospitalizations when INR was unacceptably high by treating the patient with oral vitamin-K at home. Our findings could be helpful when planning warfarin treatment in elderly, fragile patients.