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has been cited by the following article:

• TITLE: Typical Aspects of the Granular Cell Tumor of the Oral Cavity

  AUTHORS: Paula Prieto-Oliveira, Sérgio Vitorino Cardoso, Florence Zumbaio Mistro, Sérgio Kignel, Suzana Cantanhede Orsini Machado de Sousa, Marco Túllio Brazão-Silva

  KEYWORDS: Granular Cell Tumor, Mouth, Diagnosis

  JOURNAL NAME: International Journal of Otolaryngology and Head & Neck Surgery, Vol.3 No.6, October 16, 2014

  ABSTRACT: Granular cell tumor (GCT) is a rare neoplasm that can occur in any part of the body, but mostly they are located intraorally. Its histogenetic origin remains controversial, but it probably arises from Schwann cells and is generally benign. The tumor is typically asymptomatic and appears as a nodule, with a relatively high predilection for the tongue. This article reports a case of a 72-year-old woman treated at the Center of Oral Diagnosis of the Fundação Hermínio Ometto Dental School. The patient presented with an asymptomatic nodule in the dorsal surface of the tongue for approximately 4 months. The patient was submitted to an excisional biopsy and histopatological examination revealed polyhedral cells with granular aspect. The immunohistochemical staining for S-100 presented strong reactivity, confirming the diagnosis of GCT. Finally, we made a concise discussion about the pathogenesis and fundamental clinico-pathological aspects of GCT making the differential diagnosis.