Fidder, A., Hulst, A.G., Noort, D., de Ruiter, R., van der Schans, M.J., Benschop, H.P. and Langenberg, J.P. (2002) Retrospective Detection of Exposure to Organophosphorus Anti-Cholinesterases:? Mass Spectrometric Analysis of Phosphylated Human Butyrylcholinesterase. Chemical Research in Toxicology, 15, 582-590. http://dx.doi.org/10.1021/tx0101806

has been cited by the following article:

• TITLE: Improvements to the Fluoride Reactivation Method by Simple Organic Extraction for Retrospective Detection of Exposure to the Organophosphorus Nerve Agents in Human Plasma

  AUTHORS: Jin Young Lee, Yong Han Lee

  KEYWORDS: Chemical Warfare Agents, Isopropyl Methylphosphonofluoridate, Organic Extraction, Plasma

  JOURNAL NAME: International Journal of Analytical Mass Spectrometry and Chromatography, Vol.2 No.3, September 25, 2014

  ABSTRACT: A rapid and simple organic extraction method for the determination of the chemical warfare agent, isopropyl methylphosphonofluoridate (sarin, GB) in human plasma has been developed using gas chromatography-tandem mass spectrometry (GC-MS/MS). In the course of method development, several organic solvents have been screened and chloroform show a low background and increase signal to noise ratio of GB among other organic solvents. Especially, the organic extraction method of reactivated GB from the human plasma has a 30% greater recovery yield than solid-phase ex-traction (SPE). This simple extraction method was successfully applied to the trace analysis of nerve agents in human plasma in the 3rd Organisation for the Prohibition of Chemical Weapons (OPCW) confidence building exercise on biomedical sample analysis.