Article citationsMore>>
Boudreau, E.A., Johnson, K.P., Jackman, A.R., Blancato, J., Huizing, M., Bendavid, C., Jones, M.P., Chandrasekharappa, S.C., Lewy, A.J., Smith, A.C.M. and Magenis, R.E. (2009) Review of Disrupted Sleep Patterns in Smith-Magenis Syndrome and Normal Melatonin Secretion in a Patient with an Atypical Interstitial 17p11.2 Deletion. American Journal of Medical Genetics, 149, 1382-1391.
http://dx.doi.org/10.1002/ajmg.a.32846
has been cited by the following article:
-
TITLE:
Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model
AUTHORS:
Bertha Prieto Gómez, Cruz Reyes-Vázquez, Mireya Velázquez-Paniagua
KEYWORDS:
Rat, Melatonin, Hippocampus, Antioxidant, Aging
JOURNAL NAME:
Advances in Aging Research,
Vol.3 No.4,
September
18,
2014
ABSTRACT: Melatonin is a hormone synthesized and released primarily by the pineal gland. Its secretion fol-lows a circadian rhythm with a peak overnight. Its secretion is initiated approximately to the three months of age and continues to rise during the childhood. Previous to the puberty there is a de-crease of melatonin secretion that continues until the old age. Melatonin has effects in the body and acts through at least four mechanisms: membrane receptors, orphan nuclear receptors, calmodulin and free radicals. It has been suggested that aging can be a consequence of the oxidation of cells that eventually become vulnerable to injury and die. This work reviews the antioxidant effects of melatonin in a rodent model, on the formation of free radicals, on the MAP2 protein expression and on the electrophysiology of the hippocampus at different ages. The results indicate that melatonin maintains in a “best” state to the experimental animals compared to controls. It suggests the use of melatonin as a therapy to prevent or delay the aging effects on the cells.
Related Articles:
-
Geetha Chandrashekar, Ganesh Gopalakrishna, Austin Campbell, Katherine Edwards, Muaid Ithman
-
Jai Dev Chandel, Nand Lal Singh
-
Echendu Adinma, Nkiru N. Ezeama, Chukwuma D. Umeokonkwo
-
Pilar Dutari, Tantrantan Leonce Adjoumani, Marilyne Grinand, Olivier Lavelle, Moglie Le Quintrec, Safia Chebrek
-
Daouda Thioub, Aboubakar T. Ibrahim, Khardiata Diallo-Mbaye, Zande-Yindoni Jules, Ndeye A. Lakhe, Moussa Seydi