TITLE:
Elevated Ferritin Levels and the Relationship with Fasting Insulin Levels in Elderly Patients with Metabolic Syndrome
AUTHORS:
Fulden Sarac, Sumru Savas, Sefa Sarac, Fehmi Akcicek
KEYWORDS:
Metabolic Syndrome, Ferritin, Fasting Insulin, Elderly
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.3,
August
25,
2014
ABSTRACT:
Introduction: Elevated
serum ferritin levels are associated with insulin resistance, type 2 diabetes
and metabolic syndrome (MetS) as well as systemic inflammation and
cardiovascular disease. The associations between ferritin and hemoglobin levels
with individual components of MetS are unclear. The aims of the study were 1)
to compare the ferritin levels, and 2) to investigate the relationships between
ferritin, high-sensitivity CRP (hs-CRP), fasting glucose, fasting insulin and
homeostasis model assessment (HOMA-IR) levels in elderly patients. Subjects and
Methods: Study population included 121 (mean age 64.3 ± 14.1 yrs) (80 female,
41 male) elderly patients. The study population was evaluated for MetS by Adult
Treatment Panel III (ATPIII). Demographic and biochemical data such as fasting
insulin, hs-CRP, fasting glucose and ferritin levels were evaluated.
Biochemical data were evaluated retrospectively. Insulin resistance (IR) was
estimated using the HOMA. Results: Metabolic syndrome was diagnosed in 39
elderly patients (32.2%). In elderly patients with MetS, mean levels of
ferritin, hs-CRP, fasting glucose, fasting insulin and HOMA were found to be 72.9
± 33.1 ng/ml, 0.90 ± 0.01, 99.1 ± 20.1 mg/dl, 13.4 ± 1.1 μU/l, 3.0 ± 0.1,
respectively. However, mean levels of ferritin, hs-CRP, fasting glucose,
fasting insulin and HOMA were found to be 54.1 ± 33.1 ng/ml, 0.67 ± 0.1, 91.9 ±
17.0 mg/dl, 8.4 ± 2.7 μU/l, 2.71 ± 0.9, in the other elderly patients, (p= 0.0012), (p= 0.70), (p= 0.70), (p= 0.003), (p= 0.80) respectively. Mean levels
of ferritin were positively correlated with diastolic (r = 0.850,p =0.03), systolic blood pressures (r
= 0.700,p =0.02), and fasting insulin (r =
0.444,p =0.003) in elderly with MetS.
Conclusions: Mean levels of ferritin were increased in elderly patients with
metabolic syndrome. And also, ferritin levels were positively correlated with
systolic and diastolic blood pressures as well as fasting insulin but not with
hs-CRP levels in elderly patients with metabolic syndrome.