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Bartoli, C.R., Giridharan, G.A., Litwak, K.N., Sobieski, M., Prabhu, S.D., Slaughter, M.S. and, Koenig, S.C. (2010) Hemodynamic Responses to Continuous versus Pulsatile Mechanical Unloading of the Failing Left Ventricle. ASAIO Journal, 56, 410-416.
http://dx.doi.org/10.1097/MAT.0b013e3181e7bf3c
has been cited by the following article:
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TITLE:
Do Continuous Flow LVADS Improve Diastolic Dysfunction?
AUTHORS:
Nandini Nair, Sudhir Thotakura, Enrique Gongora
KEYWORDS:
Continuous Flow Device, Diastolic Function, HeartMate IITM, Left Ventricular Assist Devise
JOURNAL NAME:
Open Journal of Organ Transplant Surgery,
Vol.4 No.3,
August
5,
2014
ABSTRACT:
Background: Ventricular assist devices are now used as a bridge to recovery/decision/transplant or as destination therapy in end-stage heart failure. Continued improvements in technology and pump design have made implantation an easier process with reduced operative risks and pump-related adverse events. Considering the beneficial effects of these devices in the clinical setting, it seemed logical to address the long-term effect of the continuous flow pumps on diastolic dysfunction. Methods: This study addresses the effect of HeartMate IITM(HMII) support for 284+/-97 days on echocardiographic parameters of diastolic function. Data from fifteen patients was retrospectively studied status post left ventricular assist device (LVAD) implantation. The data at approximately 1-year post implantation was compared with that obtained prior to implantation. Statistical analyses were performed using the Microsoft Excel Program/MSExcel Stats. Echocardiographic measurements were carried out in accordance with the American Society of Echocardiography guidelines. Results: Of all the echocardiographic parameters assessed only E/Ea and calculated left atrial pressure (LAP) showed a statistically significant decrease. Two parameters that showed a trend towards significance are Ea (septal) and global functional index (p = 0.05). Conclusions: Continuous Flow LVAD support appears to improve diastolic dysfunction. This study has limitations in that we used a single type of continuous flow device (HeartMate IITM) and was conducted as a retrospective analysis. Further studies with larger populations and longer support are required to validate this finding.
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