TITLE:
The Relation between Apolipoprotein E4 Genotype and Vascular Dementia
AUTHORS:
Tomader Taha Abdel Rahman, Safia Mohamed Shehata
KEYWORDS:
Apolipoprotein E4, Cerebral Infarction, Genetics, Vascular Dementia
JOURNAL NAME:
Advances in Aging Research,
Vol.3 No.3,
July
23,
2014
ABSTRACT:
Most studies investigating genetics of
dementia have focused on Alzheimer’s disease, but little is known about the
genetics of vascular dementia (VD). The aim of this study was to identify the
association between Apolipoprotein E4 (Apo E4) genotype and VD in cerebrally
infarcted patients. The study was conducted
on 100 patients with cerebral infarction: 50 had VD (cases) and 50 didn’t have
dementia (controls). Diagnosis of VD was based on Mini-Mental State
Examination, Cambridge Cognitive Examination (CAMCOG), the Diagnostic and Statistical Manual of Mental Disorders 4th edition criteria for the diagnosis of VD (DSM-IV), Hachinski Ischemic Score, and
computed tomography of the brain (CT brain). Apo E4 allele was assessed through
DNA genotyping. The study showed that hypertension
(p = 0.027, OR = 4.71), diabetes mellitus (p = 0.003, OR = 6.05) and Apo E4
allele (p = 0.017, OR = 13.39) were the independent risk factors of VD among studied participants. The study concluded that cerebrally infarcted
patients with Apo E4 genotype are
at high risk of developing VD.