Makki, M.S.T., Bakhotmah, D.A., Abdel-Rahman, R.M. and El-Shahawy, M.S. (2012) Designing and Synthesis of New Fluorine Substituted Pyrimidine-Thion-5-Carbonitrles and the Related Derivatives as Photochemical Probe Agent for Inhibition of Vitiligo Disease. International Journal of Organic Chemistry, 2, 311-320.
http://dx.doi.org/10.4236/ijoc.2012.223043

has been cited by the following article:

• TITLE: Synthesis of New Fluorine/Phosphorus Substituted 6-(2’-Amino Phenyl)-3-Thioxo-1,2,4-Triazin-5(2H, 4H)One and Their Related Alkylated Systems as Molluscicidal Agent as against the Snails Responsible for Bilharziasis Diseases

  AUTHORS: Abeer N. Al-Romaizan, Mohammed S. T. Makki, Reda M. Abdel-Rahman

  KEYWORDS: Fluorine, Phosphorus, Sulfur-1, 2, 4-Triazine, Characteristic Properties, Molluscicidal Activity

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.4 No.2, June 27, 2014

  ABSTRACT: New fluorine substituted 6-(5’-fluoro-2’-triphenylphosphiniminophenyl) 3-thioxo-1,2,4-triazin-5 (2H, 4H) one (2) was obtained via Wittig’s reaction of the corresponding 6-(5’-fluoro-2’-amino-phenyl)-3-thioxo-1,2,4-triazinone (1). Behavior of compound 2 towards alkylating agents and/or oxidizing agents was studied were, N-hydroxyl (3), Mannich base (4,5), S-alkyl (6,7,8) and thiazolo [3,2-b][1,2,4] triazinones (10-14) and or 3-disulfide (18), 3-sulfonic acid 19 and 1,2,4-triazin-3,5-Dionne (20) derivatives obtained. Structures of the new products are established by elemental and spectral data. The new targets obtained screened as Molluscicidalagents against Biomophlaria Alexandrina snails responsible for Bilharziasis diseases, in compare with Baylucide as standard drug.