Cristina Mazon, R., Rovigatti Gerbelli, T., Benatti Neto, C., de Oliveira, M.R., Antonio Donadi, E., Guimaraes Goncalves, M.A., Garcia Soares, E., Patricia Klay, C., Tersariol, I., Aparecida Pinhal, M., Resende, L. and Pienna Soares, C. (2009) Abnormal Cell-Cycle Expression of the Proteins p27, mdm2 and Cathepsin B in Oral Squamous-Cell Carcinoma Infected with Human Papillomavirus. Acta Histochemica, 113, 109-116.
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has been cited by the following article:

• TITLE: MDM2 SNP309 (rs2279744) and p53 Codon Arg72Pro (rs1042522) SNP in Cervical Carcinogenesis

  AUTHORS: Osamu Nunobiki, Hirohide Sawada, Masatsugu Ueda

  KEYWORDS: p53, MDM2, Polymorphism, HPV, Cervical Carcinogenesis

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.5 No.7, June 20, 2014

  ABSTRACT: To investigate the association between polymorphisms (SNP) in the p53 and murine double minute 2 homolog (MDM2) promoter 309 in cervical carcinogenesis. SNP at p53 codon 72 polymorphisms and MDM2 promoter 309 (T/G) together with human papillomavirus (HPV) types were examined in a total of 187 cervical smear samples using real time PCR. 27 cases with HPV types 16 and/or 18 had significantly higher frequency of the TG + GG genotype and G allele than 56 with other types of high-risk HPV (P = 0.0136). 48 cases with HPV types 52 and/or 58 had significantly higher frequency of the TG + GG genotype and G allele than 56 with other types of high-risk HPV (P = 0.001). Our studies have demonstrated that the frequency of G allele in MDM2 promoter 309 increased from LSIL to HSIL and that there was an increased OR for G allele in HSIL cases with high-risk HPV types including 52 and 58. It is known that geographically different oncogenic HPV types 52 and 58 are more prevalent than 16 and 18 in a Japanese population.