TITLE:
Animal Models of Obsessive-Compulsive Disorder: Strain Differences
AUTHORS:
Taimon P. Maio, Guilherme B. Filgueiras, Daniel C. Cunha, Celio Estanislau
KEYWORDS:
Obsessive-Compulsive Disorder, Animal Models, Strain Differences, Individual Differences
JOURNAL NAME:
World Journal of Neuroscience,
Vol.4 No.3,
June
17,
2014
ABSTRACT:
Obsessive-compulsive
disorder (OCD) is characterized by obsessions (intrusive thoughts, images etc.)
and compulsions (repetitive, stereotyped and perseverant acts). Animal models
of OCD are specifically devoted to simulating compulsive features of the
disorder. In OCD, compulsive behaviors are recognized as repetitive and
maladaptive and symptoms relief can be experienced due to treatment with
selective serotonin reuptake inhibitors. Many animal models of OCD are provided
with some degree of validity. Genetically based differences in behavior in
animal models of OCD are of great value, given that human OCD is reported to
involve genetic factors. Some animal models of OCD were already used in studies
for the evaluation of strain differences. These works were explored in the
present review.