TITLE:
Prospective Clinical Application of Thioredoxin Reductase as a Novel Diagnostic Tumor Marker
AUTHORS:
Suofu Ye, Nong Yang, Weiwei Ma, Yanran Fu, Lin Wu, Yueqin Li, Lihui Liu, Yi Hui, Yu Qiu, Siqing Mei, Yan Li, Huihui Zeng
KEYWORDS:
Thioredoxin Reductase, Diagnostic Marker, Cancer, Malignant Tumor, TR Activity, Abnormal Hyperplasia, Proliferation
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.2 No.4,
June
12,
2014
ABSTRACT:
Background: Developing a novel, efficient
biomarker for detecting malignant tumors is essential for the early diagnosis
of cancers. Our aim was to assess the diagnostic value of a potential plasma
tumor marker, thioredoxin reductase (TR), which is expressed in many types of
malignant tumor, for the non-invasive detection of cancers. Methods: The plasma
activities of TR were measured in 1513 patients with common clinical diseases,
59 patients with benign tumors, and 154 patients with cancers and 586 healthy
controls. The area under the ROC curve (AUC) of TR and logistic regression
results of different groups were compared by sensitivity, specificity and
Youden’s index. Diagnostic cut-offs and clinical reference intervals were
established via ROC curve analysis. Results: The logistic regression indicated
that TR activity can discriminate between cancers and benign tumors or other
common diseases very well (p