Article citationsMore>>
Stoyanova, E., Sandoval, S., Zuniga, L., El-Yamani, N., Coll, E., Pastor, S., Reyes, J., Andrés, E., Ballarin, J., Xamena, N. and Marcos, R. (2009) Oxidative DNA Damage in Chronic Renal Failure Patients. Nephrology Dialysis Transplantation, 25, 879-885.
http://dx.doi.org/10.1093/ndt/gfp575
has been cited by the following article:
-
TITLE:
Oxidative DNA Damage Is Elevated in Renal Patients Undergoing Haemodialysis
AUTHORS:
Twyla Moffitt, Florence Hariton, Megan Devlin, Peter J. Garrett, Mary P. A. Hannon-Fletcher
KEYWORDS:
Haemodialysis, Modified Comet Assay, Oxidative DNA Damage
JOURNAL NAME:
Open Journal of Preventive Medicine,
Vol.4 No.6,
June
11,
2014
ABSTRACT:
Background: End
stage renal disease (ESRD) is associated with an increase in oxidative stress,
cardiovascular disease and cancer. The main treatment for ESRD is
haemodialysis (HD), which itself induces repetitive bouts of oxidative stress
through membrane biocompatibility and endotoxin challenge. The resulting higher
levels of reactive oxygen species in turn produce increased levels of oxidative
DNA damage leading to genomic instability which may influence the higher risk
of cancer reported in HD patients. Our aims were to measure levels of oxidative
DNA damage in HD patients and in age and gender matched control volunteers.
Methods: Thirty eight patients receiving HD in the Western Health and Social
Services Trust (WHSCT) and 8 healthy volunteers were recruited. Volunteers gave
informed consent and non-fasting morning blood samples were taken and assessed
for DNA disruption using the comet assay modified to identify oxidative
specific damage. Results: The HD patients had significantly elevated levels
of alkaline DNA damage (19.46% ± 1.37% vs 3.86% ± 1.36% tail DNA, p
Related Articles:
-
Twyla Moffitt, Florence Hariton, Megan Devlin, Peter J. Garrett, Mary P. A. Hannon-Fletcher
-
Guillaume Mahamat Abderraman, Ibrahim Hamat, Zeinabou Maiga Moussa Tondi, Ahmed Tall Lemrabott, Maria Faye, Cisse Mouhamadou Moustapha, Kossi Akomola Sabi, Ka Elhaj Fary Ka, Niang Abdou, Diouf Boucar
-
Bruno Otero Sutti, Luciana Lopes Guimarães, Roberto Pereira Borges, Elisabete de Santis Braga
-
Sara P Dalboni, Bianca P Campagnaro, Clarissa L Tonini, Elisardo C Vasquez, Silvana S Meyrelles
-
Guillaume Mahamat Abderraman, Ali Adam Ahamat, Charfadine Senousssi, Doune Narcisse, Mahamat Hissein Ali, Adamou Abbassi Mana, Yusra Aboulbachar, Mirene Bourdjo