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has been cited by the following article:

• TITLE: Nω-Nitro-Nω’-Substituted Guanidines: A Simple Class of Nitric Oxide Synthase Inhibitors

  AUTHORS: Christophe D. Guillon, David D. Wisnoski, Jaya Saxena, Ned D. Heindel, Diane E. Heck, Donald J. Wolff, Jeffrey D. Laskin

  KEYWORDS: Nitro-Guanidines, Nitric Oxide Synthase (NOS), Isoforms, Selective Inhibitors

  JOURNAL NAME: Modern Research in Inflammation, Vol.3 No.2, May 6, 2014

  ABSTRACT: A series of Nω-nitro-Nω’-substituted guanidines has been prepared as potential inhibitors of the human Nitric Oxide Synthase (NOS) isoforms. The reported utility of amino-guanidine and nitroarginine in iNOS inhibition points to a potential similar utility for analogs of nitro-guanidine. The compound library was tested against the three isoforms of Nitric Oxide Synthase (eNOS, iNOS and nNOS). Several candidates showed excellent activity and good selectivity for nNOS. One particular compound even demonstrated good selectivity for iNOS. The potential usefulness of such selective inhibitors is discussed.