TITLE:
In Vivo Evaluation of Titanium Implants Bioactivated by a Modified Kokubo’s Treatment
AUTHORS:
Jailson de Jesus, Enori Gemelli, Fábio Nery, Nelson H. A. Camargo
KEYWORDS:
Titanium; Thermochemical Treatment; Wettability; In Vivo Test
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.2 No.2,
April
29,
2014
ABSTRACT:
In this study a modified Kokubo’s treatment
(MKT) was used to bioactivate titanium implants. Titanium surfaces were
alumina-blasted and etched in HCl/H2SO4 solution followed by treatment in
autoclave at 120°C for 1, 3, 5 hour periods with
chemical solutions containing 1, 2 and 3 M of NaOH. The materials were characterized
by surface angle measurements, roughness, field emission scanning electron
microscopy (FE-SEM), X-ray photoelectron spectroscopy (XPS), and in vivo tests.
Statistical analysis by polynomial regression showed that solutions within 2.2
and 2.8 M
NaOH lead to surface contact angles close to zero degree after 1 h of
treatment. XPS analysis carried out on a sample treated 1 h in 2.2 M NaOH indicated the
presence of a titanate film. This solution was selected to treat titanium implants
for in vivo tests. These tests were performed on sheep in three types of
separating surfaces: machined group (standard), SLA group (A) and MKT group (B)
divided into two time intervals of 3 and 6 weeks. The samples in group B
displayed better results compared to group A only after 6 weeks in terms of
counter torque and bone implant contact (BIC).