TITLE:
Effectiveness of Laser Therapy (AlGaInP) on Cicatrization of Experimental Cutaneous Wound in Rats
AUTHORS:
Renata dos Santos Vasconcelos, Renata Prado Vasconcelos, Luana Torres Monteiro Melo, Carolina Araújo Castro, Adriana Rolim Campos, Ana Paula Vasconcellos Abdon
KEYWORDS:
Laser Therapy, Rats, Wound Healing, Regeneration
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.5 No.9,
April
25,
2014
ABSTRACT:
The use of laser therapy is one of the most
effective tools in the prevention and treatment of skin ulcers. It is an
effective treatment choice because it potentiates the trophic regenerative, anti
inflammatory, and painkiller effects. This study aimed to assess the
effectiveness of low level laser therapy in treating induced cutaneous ulcers
in rats. An experimental study using 12 female Wistar rats (Rattus novergicus),
weighing between 150 and 250 g, from the room of animal husbandry at the Center
of Health Sciences of UNIFOR. Rats underwent surgery to induce cutaneous ulcer.
Subsequently, the animals were divided into two randomized groups: 1) Control
group; and 2) Experimental group. They received nine applications of AlGaInP
laser treatment (power of 30 mW) with an intensity of 4 J/cm2, using
the scan method, for 15 seconds over the entire ulcer. The cicatrization
process was evaluated from the 1st to 19th postoperative
(PO) day, but on alternate days. The results showed that animals treated with
laser had less area of cutaneous wound than the control group from the 7th until the 17th postoperative day, highlighting the 7th and the 9th PO with a significant reduction in wound area of 28.8%
(p = 0.00) and 23,5% (p = 0.01), respectively. Treatment with the AlGaInP laser
was effective in the repair of cutaneous wound when compared to the control
group—particularly on the 7th postoperative day.