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http://dx.doi.org/10.1124/mol.62.3.647

has been cited by the following article:

• TITLE: Gene Regulation of Catecholamine Biosynthetic Enzymes by Nitric Oxide in PC12 Cells

  AUTHORS: Dominique Ansell, Julie Grandbois, T. C. Tai

  KEYWORDS: NO, PC12 Cells, TH, DBH, PNMT, Catecholamines

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.4 No.4, April 25, 2014

  ABSTRACT: Nitric oxide (NO) regulates a wide range of physiological processes. Recent studies show that NO can regulate the release of catecholamines (CA) from the adrenal medulla. In the current study, the PC12 cell line was used to examine the effect of NO on the regulation of the CA biosynthetic enzymes: tyrosine hydroxylase (TH), dopamine-β-hydroxylase (DBH) and phenylethanolamine Nmethyltransferase (PNMT). Treatment of PC12 cells with the NO donor, sodium nitroprusside (SNP) for 6 hours significantly increased TH, DBH and PNMT mRNA levels. In addition, NO potentiates the regulation of gene expression of all three CA biosynthetic enzymes by glucocorticoids and cholinergic agonists. The signaling pathways involved in NO regulation of CA biosynthetic enzymes were investigated with the use of specific kinase activators and inhibitors, with results supporting a contributing role of PKA, PKC and PKG in SNP-mediated induction for all three CA genes (p