TITLE:
Alteration of Sex and Non-Sex Hormones and Distribution Features of Blood ABO System Groups among the Women with Uterine Body Tumors
AUTHORS:
Irina Nakashidze, Anzor Diasamidze, Davit Baratashvili, Marina Nagervadze, Manana Alibegashvili, Liana Ramishvili, Manana Gordeziani, Ana Khazaradze, Nanuli Kotrikadze
KEYWORDS:
Uterine Body Tumors, Hormones, Benign Tumor, Malignant Tumor, Blood ABO System
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.5,
April
23,
2014
ABSTRACT:
Objectives: The aim of the
investigation was to study the hormonal status (sex hormones: estradiol (E2),
progesterone (P), testosterone (T); non-sex gonadotropic hormones-luteinizing
hormone (LH) and follicle-stimulating hormone (FSH)) of women with benign and
malignant tumors of uterine body in the reproductive, menopause and
postmenopause periods. Also the
distribution features of the blood ABO system phenotype groups and their link
to the development of uterine body tumors have been studied. Methods: The determination of hormones was made
by the enzyme analysis method (ELAIZA),
provided by the proper ELAIZA kits. For
the study of blood ABO system antigens, internationally recognized immunoserology
methods were used. Results:
Investigations revealed the increased level of E2 and T on the background of the reduced
P in the blood of the women with uterine tumors in the reproductive, menopause and post-menopause period.
As for gonadotropic hormones, the decreased levels of LH and FSH have also been
detected. From the ABO system phenotype groups A(II) group had the highest
frequency between the women with malignant uterine tumor in the reproductive
age. O (I) phenotype group was the most frequent in case of menopause and
post-menopause women with uterine malignant tumors. Conclusions: Hormonal
imbalance creates good conditions for the proliferation of uterine tissues and
hence causes the development of benign and malignant uterine tumors. The imbalance
of the sex steroid and gonadotropic hormones in the blood of post-menopause
women indicates on the genotoxic mechanism of cancer development on the
background of age-related changes. A(II) group had the highest frequency
between the reproductive age women with uterine malignant tumor, while O (I)
group was the most frequent in case of menopause and post-menopause patients.