TITLE:
Pseudomyogenic Hemangioendothelioma of Bone Initially Managed as Slipped Capital Femoral Epiphysis: A Case Report
AUTHORS:
Nicole A. Friel, Adam C. Rothenberg, Kurt Weiss
KEYWORDS:
Pseudomyogenic Hemangioendothelioma, Slipped Capital Femoral Epiphysis, Sarcoma, Epithelioid
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.4,
March
31,
2014
ABSTRACT:
Pseudomyogenic
hemangioendothelioma is a rare, recently described neoplasm that
usually presents as multifocal lesions in a single extremity. The disease has
demonstrated a high propensity for infiltrative growth and local recurrence but
limited metastatic potential. Variations of histological appearance and
immunohistochemical signatures have been described, but typically involve
spindle or polygonal cells with nuclear atypia and neutrophilic infiltration.
Here we present a case report of an 8-year-old female who presented with hip
pain that was initially diagnosed and managed as a slipped capital femoral
epiphysis (SCFE). Subsequent evaluation led to the diagnosis of pseudomyogenic
hemangioendothelioma of bone. Due to the degree of osseous destruction,
described patterns of local recurrence, and metastatic potential of this
neoplasm, a wide resection with endoprosthetic reconstruction of the proximal
femur was performed. This case highlights the importance of due diligence in
the diagnoses of SCFE and bone tumors in young patients with abnormalities of
the proximal femur, including consideration of the need for biopsy.