TITLE:
Prevalence of Human Leukocyte Antigen HLA-B*5701 in HIV-1 Infected Individuals in Brazil
AUTHORS:
Claudinéia de Araújo, Cristina Valetta de Carvalho, Miriam Estela de Souza Freire, Amanda Yamaguti, Ivens Cuiabano Scaff, Fernando José de Souza, Flávia Galindo Silvestre Silva, Ricardo Sobhie Diaz, Ismael Dale Cotrim Guerreiro da Silva
KEYWORDS:
Immunogenetics; Human Immunodeficiency Virus; HLA-B*5701 Antigen Human; Abacavir
JOURNAL NAME:
Open Journal of Genetics,
Vol.4 No.1,
March
21,
2014
ABSTRACT:
This study was designed to establish the prevalence of
HLA-B*5701 at HIV-1 infected individuals in Brazil. A total of 517 consecutive
individuals were followed in this study from February 2009 through July 2011. The presence of HLA-B*5701 was
determined by Nested-PCR with HLA-B*57 and HLA-B*5701 sequence-specific primers (PCR-SSP). The expression of
HLA-B*57 was negative in the 385 (74.5%) and positive in the
103 (19.9%) of infected
individuals. Among these, the expression of HLA-B5701
was positive in the 29 (5.6%) of individuals. No demographic or ethnic
differences were found between HLA-B*57/HLA-B*5701
HIV-1 negative patients, with a prevalence of Caucasians (57.1%) individuals.
During the period
of study, 68 patients were submited to an abacavir contain- ing regimen. The HLA-B*5701
allele was observed in 7 (10.3%)
patients, with a significant incidence of Hypersensitivity reactions at 4 of them (p