TITLE:
Prevalence of Metabolic Syndrome in HIV-Infected Cameroonian Patients
AUTHORS:
Henriette Thérèse Dimodi, Lucien Sone Etame, Boris Signing Nguimkeng, Florine Essouman Mbappe, Nadine Essola Ndoe, Jacob Nkougni Tchinda, J. Justin Abega Ebene, Françoise Raïssa Ntentié, G. Boris Azantsa Kingue, Mary-Ann Mbong Angie, Ghislain Djiokeng Paka, Charles Kouanfack, Judith Laure Ngondi, Julius Oben Enyong
KEYWORDS:
HIV; Antiretroviral Drugs; Abdominal Obesity; Dyslipidemia; Hypertension; Hyperglycemia; Metabolic Syndrome; Prevalence
JOURNAL NAME:
World Journal of AIDS,
Vol.4 No.1,
March
21,
2014
ABSTRACT:
Aims: Metabolic complications
related to antiretroviral therapy are rarely investigated among HIV-infected
patients in Cameroon. The study reports the prevalence of metabolic syndrome
and its individual components among HIV-infected Cameroonians. Materials and
Methods: We conducted a prospective, cross-sectional study of the prevalence of
metabolic syndrome among 492 patients (338 women, 117 men; age range 20 years) recruited at a reference centre, the
day hospital, Central Hospital in Yaounde between September 2009 and September
2010. Metabolic syndrome was defined according to IDF (International Diabetes
Federation) and NCEP ATP III (National Cholesterol Education Program Adult
Treatment Panel III) criteria relative to obesity, glycemic, lipid, arterial
blood pressure parameters. Results: The prevalence of metabolic syndrome was 32.8% according to IDF and 30.7% by NCEP (p =
0.0001). The prevalences of individual components according to IDF and NCEP
were as follows: abdominal
obesity (40.5%; 26.9% respectively), hypertriglyceridemia (55.5%), low HDL cholesterol (42.5%), systolic hypertension (38.2%)
diastolic hypertension (28.5%), hyperglycemia (31.2%; 1.3% p = 0.0001). The
prevalence of metabolic syndrome was 36% in patients under HAART, 23.4% in
naive, (p = 0.0001). Conclusion: The prevalence of metabolic syndrome depends
on the presence and the type of HAART used, the
definition and the gender.