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has been cited by the following article:

• TITLE: Partial IVC Clamping Improves Intraoperative Hemodynamic Parameters in the Rodent Portacaval Anastomosis Model

  AUTHORS: Mehrdad Asgeri, Nisheet Waghray, Kevin Mullen, Nader Nader, Henri Brunengraber, Juan Sanabria

  KEYWORDS: Portacaval Anastomosis, Portosystemic Shunt, Microvascular Surgery, Ivc Clamping, Surgical Technique, Encephalopathy-Like Rodent Model

  JOURNAL NAME: Surgical Science, Vol.2 No.2, April 2, 2011

  ABSTRACT: The mechanisms involved in the development of hepatic encephalopathy still remain uncertain. The rodent portacaval shunt is a model that reproduces many of the pathological features observed in humans (1), but is a technically demanding exercise. While the traditional technique involves complete occlusion of the IVC, a c-clamp was fashioned to partially clamp the IVC thereby sustaining venous return and cardiac output. The aim of this study is to determine if the c-clamp technique provides greater hemodynamic stability and enhances the success rate of the portacaval shunt procedure. To answer this question, two experimental groups, c-clamp (N = 7) and cross-clamp (N = 7), and a sham group (N = 3) were included. Intraoperative hemodynamic parameters were recorded at specific times during the procedure. The c-clamp group showed greater hemodynamic stability when compared to the cross-clamp group. It was manifested by 1) significantly higher mean arterial blood pressure [63 (range, 8) vs 47 (range, 10) mmHg, p