Cadranel, J.F., Denis, J., Pauwels, A., et al. (1999) Prevalence and Risk Factors of Bacteriuria in Cirrhotic Patients: A Prospective Case Control Multicenter Study in 244 Patients. Journal of Hepatology, 31, 464-468.
http://dx.doi.org/10.1016/S0168-8278(99)80038-5
-
TITLE:
Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study
AUTHORS:
Iftikhar Haider Naqvi, Khalid Mahmood, Abu Talib, Mohammad Ubaid, Aamer Mahmood
KEYWORDS:
Liver Cirrhosis; Proton Pump Inhibitors; Ascites; Bacterial Infections
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.4 No.3,
March
11,
2014
ABSTRACT: Cirrhosis is an immunocompromised state that leads to various infections, with an estimated 30% mortality. Pakistan already has a high morbidity and mortality related to complications of cirrhosis. Where the data on infection among cirrhotics is scanty, this study aimed to determine the frequency, microbiological spectrum and various risk factors of infections in cirrhosis of liver. This is a prospective cohort study conducted at a tertiary care hospital. The microbiological spectrum and frequency of infections was determined in cirrhotics. Various risk factors for infection among cirrhotics were evaluated like upper gastrointestinal bleed, use of proton pump inhibitors, malnutrition and severity of cirrhosis. Out of eleven hundred and forty-one patients with cirrhosis of liver, four hundred and ninety (42.94%) patients had infections. All kinds of infections like peritoneal, respiratory, urinary tract and skin were present in cirrhosis of liver where ascitic fluid infections (AFI) were the commonest i.e. 44.89%. The risk factors for bacterial infections among patients with cirrhosis of liver were upper gastrointestinal bleeding (odd ratio = 4.57, p = 0.0001), use of proton pump inhibitors (odd ratio = 2.57, p = 0.0001), degree of malnutrition (odd ratio = 10.34, p = 0.0001) and severity of cirrhosis (odd ratio = 12.99, p = 0.000). All types of infections occurred with varying frequency in cirrhosis of liver. Upper gastrointestinal bleeding, severity of cirrhosis, use of high dose proton pump inhibitors and severe malnutrition are important risk factors for infections among cirrhotics.
Related Articles:
Prevalence of Asymptomatic Bacteriuria in HIV Infected Patients in a Tertiary Hospital in Lagos, Nigeria
Akinsegun Akinbami, Ibidun Bode-Shojobi, Sarah Ajibola, Olajumoke Oshinaike, Adewumi Adediran, Olaitan Ojelabi, Kamal Ismail, Bodunrin Osikomaiya
DOI:
10.4236/wja.2013.32014
3,599 Downloads 5,753 Views Citations
Pub. Date:
June
5,
2013
A candidate identification questionnaire for postmenopausal osteoporosis patients switched from daily or weekly bisphosphonate to once-monthly ibandronate: An open, prospective, multicenter study—BONCURE study
Yesim Gokce Kutsal, Nurten Eskiyurt, Jale Irdesel, Vesile Sepici, Hatice Ugurlu, Yesim Kirazli, Fusun Ardic, Mirko Korsic, Tonko Vlak, Mane Grlickov, Snezana Markovic Temelkova, Miroslav Lazarov, Nada Pilipovic, Vera Popovic, Aleksandar Dimic, Branka Kovacev, Dorina Ruci, Argjend Tafaj, Elma Kucukalic-Selimovic, Dijana Avdic, Hajrija Seleskovic, Snjezana Pejicic, Bulent Butun, Gulseren Akyuz, Lale Cerrahoglu, Omer Faruk Sendur, Peyman Yalcin, Sema Oncel, Merih Saridogan, Tunay Sarpel, Mehmet Tosun, Kazim Senel, Savas Gursoy, Ferhan Canturk, Huseyin Demir, Blazenka Miskic, Dalibor Krpan, Franjo Skreb, Simeon Grazio, Zeljka Crncevic-Orlic, Fatih Ozdener, Hakan Oncel
DOI:
10.4236/health.2013.57A2004
4,385 Downloads 6,337 Views Citations
Pub. Date:
July
16,
2013
