TITLE:
Clinical Pathological Correlation Quiz: A 7-Month-Old Girl with Congenital Neutropenia and Increased Bone Morrow “Blasts”
AUTHORS:
Ruchika Sharma, Jessica A. Hemminger, Samir B. Kahwash
KEYWORDS:
Neutropenia; Hematogones; ELANE Mutation; Acute Leukemia
JOURNAL NAME:
Open Journal of Pathology,
Vol.4 No.1,
January
7,
2014
ABSTRACT:
Persistent
Neutropenia in a child presents a wide differential diagnosis, spanning the
spectrum of benign disorders (such as congenital neutropenia, cyclic
neutropenia, etc.) to malignant processes (such as myelodysplasia or acute
leukemia). The morphologic findings in the bone marrow of a patient with neutropenia
may show considerable overlap with those seen in hematopoietic malignancies. We
present herein a case that demonstrates this overlap and discuss features that
can help in avoiding diagnostic pitfalls.