TITLE:
Clinical Significance of Platelet-Derived Growth Factor-C Expression in Colorectal Cancer
AUTHORS:
Shinichi Yamauchi, Satoru Iida, Megumi Ishiguro, Toshiaki Ishikawa, Hiroyuki Uetake, Kenichi Sugihara
KEYWORDS:
Platelet-Derived Growth Factor-C; Colorectal Cancer; Prognosis, mRNA Expression; Immunohistochemistry
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.1,
December
27,
2013
ABSTRACT:
Platelet-derived growth factors (PDGFs) are known to be associated with
tumor growth and angiogenesis through their activation of the receptor tyrosine
kinases, PDGF receptors alpha and beta. Several studies revealed the
participation of the PDGF family in colorectal cancer (CRC). However, the role
of platelet derived growth factor-C (PDGFC) in CRC is less well studied. This
study aimed to determine the correlation between PDGFC expression and the
prognosis of patients with CRCs. Tumor samples were obtained from patients with
CRC who underwent surgical resection between 2002 and 2006. The mRNA expression
of PDGFC was investigated by quantitative reverse transcription-polymerase
chain reaction in 85 patients with stage I-IV CRC. PDGFC protein expression was
analyzed by immunohistochemistry, and the relationship between PDGFC protein
expression and clinicopathologic features was investigated in 245 patients with
stage I-III CRC. PDGFC mRNA expression in cancer tissues was significantly
higher in patients with distant metastases than in those without metastases (P = 0.016). PDGFC protein overexpression
was associated with significantly worse overall and relapse-free survival (P P - 6.081, P