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S. Uchino, J. A. Kellum, R. Bellomo, G. S. Doig, H. Morimatsu, S. Morgera, et al., “Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Acute Renal Failure in Critically ill Patients: A Multinational, Multicenter Study,” JAMA, Vol. 294, 2005, pp. 813-818.

has been cited by the following article:

  • TITLE: Short Term Prognostic Utility of Tc-99m DMSA Renal Imaging in Sepsis Induced Acute Renal Failure; Provisional Data

    AUTHORS: Amr Amin, Hatem Nasr, Gehan Younis, Hatem Gamal

    KEYWORDS: Acute Renal Failure; Tc-99m DMSA; Sepsis Induced Acute Renal Failure

    JOURNAL NAME: International Journal of Clinical Medicine, Vol.4 No.12, December 25, 2013

    ABSTRACT: Background: Sound prognostic data in sepsis induced acute renal failure (SARF) are lacking especially on the short term outcome [STO] in the intensive care unit [ICU]. We addressed the use of Tc-99m DMSA [2,3-dimercaptosuccinicacid] renal cortical imaging as a prognostic tool in SARF. Methods: Forty patients with acute renal failure due to sepsis [age range 15-74 years; median 44.5] were subjected for full history taking complete physical examination, routine ICU monitoring, routine laboratory investigations, APACHE II [Acute Physiology and Chronic Health Evaluation] and SOFA [Sequential Organ Failure Assessment] together with Tc-99m DMSA cortical renal scintigraphy. Patients’ death in the ICU or discharge was considered as the end point of the study representing the so-called short term outcome [STO]. Results: 25% mortality rate [10/40] was found along the admission period in the ICU. All non-survivors were abnormal with DMSA imaging [NPV & PPV 100% & 66.7% respectively]. Abnormal DMSA cases showed significant positive associations with serum creatinine at admission [r = 0.5; P 0.02]; admission duration [r = 0.4; P 0.002]; APACHE II score [r = 0.5; P 0.004] and STO [r = 0.4; P 0.03]. Statistically significant difference was elicited between subjects with normal and abnormal DMSA regarding the same parameters. Conclusion: This preliminary data could raise Tc-99m DMSA renal imaging as a prognostic tool in SARF that could allow influential interference to prohibit dramatic outcomes as mortality.