TITLE:
Predictability and Management of OARs Toxicity in Patients with Prostate Cancer Treated with High-Dose Radiotherapy
AUTHORS:
Vincenzo Ravo, Domenico Borrelli, Sara Falivene, Rossella Di Franco, Matteo Muto, Angela Argenone, Valentina Borzillo, Fabrizio Cammarota, Paolo Muto
KEYWORDS:
Toxicity; Radiotherapy; Prostate Cancer; Prevention
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.10,
December
13,
2013
ABSTRACT:
Aim: To evaluate the predictability of toxicity
analyzing the dose-volume histograms (DVHs) and to verify the effectiveness of
preventive measures limiting side toxicity considering the evolution of the
radiation techniques for prostate cancer treatment. Materials and Methods: 208 patients with localized prostate cancer
were treated with exclusive radiotherapy until 73.8 Gy (group A) or 79.2 Gy (group B) with the dose escalation technique.
Preventive measures to minimize the side effects were recommended in group B. Results: The assessment of
genitourinary toxicity was similar while gastrointestinal toxicity was better
in group B. Valuating the treatment plans, we found that most of the patients developing toxicity had “borderline”
DVHs. Conclusion: Our analysis led
to the establishment of a protocol for the management of patients with
“border-line” DVH.