TITLE:
Synthesis of C-8 alkyl xanthines by pentaamminecobalt(III) complex
AUTHORS:
Renuka Suravajhala
KEYWORDS:
Alkyl Hydrazine; Radical Alkylation; Caffeine; Homolytic Aromatic Substitution; Pentaamminecobalt(III)
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.3 No.6,
December
12,
2013
ABSTRACT:
Alkyl xanthines underwent
selective homolytic aromatic substitution at C-8 position with alkyl groups of
pentaamminecobalt(III) complex. In this process of synthesis, we used monoalkyl
hydrazines as the radical source in aqueous ammonia solution. Evidence supporting
coordination of the alkyl hydrazine to pentaamminecobalt(III) complex by
radical trapping was in good agreement with literature. The products were
characterized using GC-MS and 1H, 14N and 59Co
NMR spectroscopy.