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Gurd, B.J., Little, J.P. and Perry, C.G.R. (2012) Last word on viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: Differ- ences between in vitro and in vivo experiments? Journal of Applied Physiology, 112, 931-931.
http://dx.doi.org/10.1152/japplphysiol.00078.2012

has been cited by the following article:

  • TITLE: Extremely low-volume, high-intensity interval training improves exercise capacity and increases mitochondrial protein content in human skeletal muscle

    AUTHORS: Jasmin K. Ma, Trisha D. Scribbans, Brittany A. Edgett, J. Colin Boyd, Craig A. Simpson, Jonathan P. Little, Brendon J. Gurd

    KEYWORDS: PGC-1α; Mitochondrial Biogenesis; High-Intensity Interval Training; SIRT1; Aerobic Fitness

    JOURNAL NAME: Open Journal of Molecular and Integrative Physiology, Vol.3 No.4, November 21, 2013

    ABSTRACT: Purpose: The purpose of the present study was to evaluate whole-muscle content of several proteins involved in the regulation of skeletal muscle mitochondrial protein content and anaerobic capacity following 4 weeks of extremely low-volume high-intensity interval training (HIT). Methods: Young, healthy, recreationally active adult males (n = 8) trained 4 times a week for 4 weeks on a cycle ergometer. Each session involved 4 min of total exercise comprised of eight 20 s intervals at ~170% of peak aerobic power separated by 10 s rest. Muscle biopsies were taken prior to (pre) and ~72 hrs post-training (post). Par- ticipants completed an incremental peak oxygen up- take (VO2peak) test and a Wingate test pre-, mid-, and post-training. Results: VO2peak was elevated (p p -1·min-1, mid: 43.4 ± 2.5 ml·kg-1·min-1, post-: 47.2 ± 2.9 ml·kg-1·min-1). Wingate mean power also increased with training (pre-: 701.0 ± 73.0 W, mid-: 745.5 ± 73.3 W, post-: 786.8 ± 80.0 W). While maximal citrate synthase activity was unchanged, protein expression of the mitochondrial protein cytochrome c oxidase (COX) subunit I (+27%; p p p = 0.08) increased. Increases (p α (+19%), and nuclear PGC-1α (+46%) were also observed after 4 weeks of HIT. No changes were observed in the whole-muscle contents of PDHe1a, PDK4, SIRT1, mTOR, S6K1, MCT1, or PFK protein. Conclusions: These results demonstrate that several mitochondrial protein (but not citrate synthase activity), PGC-1α protein content, and exercise capacity can be improved in only 4 min of total training time per day, 4 days per wk using HIT cycle training.