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Chu RL,Post DE,Khuri FR,et al.Use of Replicating Oncolytic Adenoviruses in Combination Therapy for Ca-neer.Clinical Cancer Research .2004; 10(16): 5299- 5312.

has been cited by the following article:

  • TITLE: Antitumor Effects of Conditional Replication Adenovirus in Combination with Cisplatin on Lung Cancer

    AUTHORS: Yanan Liu, Yinghui Huang

    KEYWORDS: Lung Cancer; Adenovirus; Cisplatin

    JOURNAL NAME: Engineering, Vol.4 No.10B, October 21, 2013

    ABSTRACT: Object: To explore the therapeutic effects and therapeutic mechanisms of Conditional Replication Adenovirus(CRAd) in combination with cisplatin on lung cancer cells. Methods: Using MTS / PMS assay, in vitro cell inhibition assay was performed to detect the cell viability of two lung cancer cell lines, NCI-H292 and NCI-H661. PCR was employed to detect the Coxsackie receptor(CAR) expression of cancer cells. The in vivo anti-tumor effect of CRAd and cisplatin was evaluated using a subcutaneous mouse model. Results: The CRAd with cisplatin is superior to the use of cisplatin or CRAd viruse alone on the suppression of lung cancer cell growth. The mechanism of inhibition is associated with the increased CAR expression. Conclusion: The application of CRAd in combination with cisplatin could play a better therapeutic effect on lung cancer cell growth inhibition.