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I. Lukaszewska and G. Niewiadomska, “The Differences in Learning Abilities between Spontaneously Hypertensive (SHR) and Wistar Normotensive Rats Are Cue Dependent,” Neurobiology of Learning and Memory, Vol. 63, No. 1, 1995, pp. 43-53. doi:10.1006/nlme.1995.1004

has been cited by the following article:

  • TITLE: Enrichment Discrimination Behavior in Spontaneously Hypertensive Rats

    AUTHORS: Ramiz M. Salimov, Georgy I. Kovalev

    KEYWORDS: Attention Deficit; Enrichment Discrimination; Spontaneously Hypertensive Rat; Atomoxetine

    JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.2 No.4, November 30, 2012

    ABSTRACT: Objectives: 1) To reveal, among spontaneously hypertensive rats, subpopulations that diverge in attention to objects enriching an empty cross-maze; 2) To evaluate effect of clinically efficient drug for treatment of attention deficiency atomoxetine on the attention to environmental cues in attentionally-low rats. Method: A novel paradigm that provides measure of attention towards enriching objects independent of general locomotor activity and spatial orientation is employed. The apparatus consists of 4-arm radial maze, two arms of which contain objects (enriched compartments). Animals exploring the objects typically stay longer in enriched parts of maze than in empty arms and have a higher score of enrichment discrimination ratio. Results: Frequency distribution of the enrichment discrimination ratio had clear bimodal shape that differed significantly from normal distribution suggesting the existence of subpopulations of attentionally-low and -high individuals. The attentionally-low phenotype did not show inferiority in spatial orientation as compared with attentionally-high phenotype. The phenotypes did not differ from each other in measures of locomo- tor activity and blood pressure. Atomoxetine (3 mg/kg, orally, once daily for 4 days) enhanced enrichment discrimina- tion in animals of attentionally-low phenotype. Single administration of the drug was ineffective. Conclusion: Popula- tion of spontaneously hypertensive rat includes two phenotypes of attentionally-low and -high individuals. Subchronic atomoxetine ameliorates attention to environmental cues in attentionally-low rats. The enrichment discrimination test could be useful in studies of neurobiology of attention deficit condition and for screening of novel drug candidates.