Ginalski, K. & Rychlewski L. Protein structure prediction of CASP5 comparative modeling and fold recognition targets using consensus alignment approach and 3D assessment. Proteins 2003, 53(Suppl. 6)410–417. - References

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Ginalski, K. & Rychlewski L. Protein structure prediction of CASP5 comparative modeling and fold recognition targets using consensus alignment approach and 3D assessment. Proteins 2003, 53(Suppl. 6):410–417.

has been cited by the following article:

TITLE: Sequence based prediction of relative solvent accessibility using two-stage support vector regression with confidence values

AUTHORS: Ke Chen, Michal Kurgan, Lukasz Kurgan

KEYWORDS: relative solvent accessibility; support vector regression; PSI-BLAST; PSI-PRED; secondary protein structure

JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.1 No.1, June 6, 2008

ABSTRACT: Predicted relative solvent accessibility (RSA) provides useful information for prediction of binding sites and reconstruction of the 3D-structure based on a protein sequence. Recent years observed development of several RSA prediction methods including those that generate real values and those that predict discrete states (buried vs. exposed). We propose a novel method for real value prediction that aims at minimizing the prediction error when compared with six existing methods. The proposed method is based on a two-stage Support Vector Regression (SVR) predictor. The improved prediction quality is a result of the developed composite sequence representation, which includes a custom-selected subset of features from the PSI-BLAST profile, secondary structure predicted with PSI-PRED, and binary code that indicates position of a given residue with respect to sequence termini. Cross validation tests on a benchmark dataset show that our method achieves 14.3 mean absolute error and 0.68 correlation. We also propose a confidence value that is associated with each predicted RSA values. The confidence is computed based on the difference in predictions from the two-stage SVR and a second two-stage Linear Regression (LR) predictor. The confidence values can be used to indicate the quality of the output RSA predictions.