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Baures, P.W., Eggleston, D.S., Erhard, K.F., Cieslinski, L.B., Torphy, T.J. and Christensen, S.B. (1993) The Crystal Structure, Absolute Configuration, and Phosphodiesterase Inhibitory Activity of (+)-1-(4-Bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one. Journal of Medicinal Chemistry, 3622, 3274- 3277. https://doi.org/10.1021/jm00074a007
has been cited by the following article:
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TITLE:
An Efficient Synthesis of Enantiomerically Pure γ-Aminobutyric Acid (GABA) Derivatives
AUTHORS:
Huixia Liu, Jiani Yuan, Qinqin Tian, Nan Ji, Wei He
KEYWORDS:
Chiral, GABA, Organocatalyst, Asymmetric Michael Addition
JOURNAL NAME:
Journal of Materials Science and Chemical Engineering,
Vol.5 No.8,
August
11,
2017
ABSTRACT:
Chiral γ-aminobutyric acid (GABA) derivatives are the normal inhibitory neurotransmitters in the mammalian central nervous system. In this paper, enantiopure GABA derivatives 6 were synthesized via reduction/cyclization/hydrolysis cascade reactions from the highly enantioselective β-aryl-γ- ni-troalkanes Michael adducts 4, which was obtained from asymmetric Michael addition of S, S’-diphenyldithiomalonate 2 to trans-β-nitroolefins 1, using novel chiral cinchona alkaloid-derived thioureas 3 as the organocatalysts. This synthesis represents an efficient, highly selective and environmental benign methodology for GABA derivatives.