TITLE:
Efficacy and Risk Factors Associated to Resistance to Single-Agent Chemotherapy in Low-Risk Gestational Trophoblastic Neoplasia
AUTHORS:
Mamour Gueye, Mame Diarra Ndiaye-Gueye, Serigne Modou Kane-Gueye, Fatou Niass Dia, Aissatou Thiam, Sr. Elisabeth Diouf, Jean Charles Moreau
KEYWORDS:
Gestational Trophoblastic Neoplasia, Chemotherapy, International Federation of Gynecology and Obstetrics, Resistance
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.6 No.1,
January
21,
2016
ABSTRACT: Objectives: This study aimed to assess efficacy of
intramuscular methotrexate 8-day protocol in the treatment of low-risk
gestational trophoblastic neoplasia and also identify prognostic factors
associated with treatment failure, necessitating second line chemotherapy.
Methods: This study was performed at Gynaecologic and Obstetric Clinic of Dakar
Teaching Hospital, the reference Centre of Gestational Trophoblastic Disease in
Senegal. At the beginning of 2011, patients were followed according to FIGO’s
recommendations. From 2011 to 2014, we diagnosed 88 low-risk gestational
trophoblastic neoplasia (GTN) patients (WHO score