TITLE:
Synthesis of (2S,4S)-2-Substituted-3- (3-Sulfanylpropanoyl)-6- Oxohexahydropyrimidine-4-Carboxylic Acids as Potential Antihypertensive Drugs
AUTHORS:
Andrei Ershov, Dmitry Nasledov, Igor Lagoda, Valery Shamanin
KEYWORDS:
Synthesis of (2S, 4S)-2-Substituted-3- (3-Sulfanylpropanoyl)-6- Oxohexahydropyrimidine-4-Carboxylic Acids as Potential Antihypertensive Drugs
JOURNAL NAME:
Journal of Materials Science and Chemical Engineering,
Vol.3 No.6,
June
11,
2015
ABSTRACT:
Proceeding from natural amino acid L-asparagine
and commercially available aldehydes a stereoselective synthesis was developed
of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohexahy- dropyrimidine-4-carboxylic
acids, potential antihypertensive drugs, inhibitors of the angiotensin converting
enzyme.