TITLE:
Thrombotic Microangiopathy Induced by Hyperthermal Intraperitoneal Chemotherapy with Mitomycin C
AUTHORS:
Mahir Köksal, Robert J van Ginkel, Jan G Zijlstra
KEYWORDS:
HIPEC, Toxicity, HUS-TTP
JOURNAL NAME:
Surgical Science,
Vol.2 No.4,
June
23,
2011
ABSTRACT: A patient with pseudomyxoma peritonei underwent Hyperthermal Intraperitoneal Chemotherapy (HIPEC) with Mitomycin C after which she developed thrombotic microangiopathy. This syndrome mimicked possi-ble surgical complications. Treatment with plasma exchange resolved the syndrome and the patient recov-ered completely. This is the first description of thrombotic microangiopathy early after a single dose intrap-eritoneal Mitomycin C.