TITLE:
Paraoxonase 2 Gene (Cys311-Ser) Polymorphism and the Risk of Coronary Artery Disease
AUTHORS:
Mohamed Fahmy Elnoamany, Ashraf Abdelraouf Dawood, Rania Mohamed Azmy
KEYWORDS:
Paraoxonase 2, Coronary Artery Disease, Polymorphism, Atherosclerosis
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.4 No.9,
August
26,
2014
ABSTRACT:
Background: Human paraoxonase-2(PON2) which is exclusively intracellular
possesses unique properities that distinguish it from PON1 and PON3. Recently,
it was demonstrated that PON2 protects against atherosclerosis by preventing
LDL oxidation. Emerging evidences have proposed that genetic variations in the
PON2 gene may be associated with coronary artery disease (CAD). Objectives: To
investigate the relationship between a common PON2 gene (Cys311-Ser)
polymorphism and the presence and extent of CAD. Methods: The study comprised
112 patients recruited from those undergoing coronary angiography for suspected
CAD, who were divided according to the presence or absence of CAD into 2 groups
Group I including 62 patients with CAD and Group II including 50 patients
proved to have normal coronaries. All the subjects included in the study were
genotyped for the (Cys311-Ser) polymorphism of PON2 gene using RCR-RFLP.
Results: The frequency of Cys allele was significantly higher in group I
compared to Group II (77.4% vs. 56% respectively, P 311 Cys allele [OR 5.67, CI
(1.99 - 14.77), P