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Collaborators C-2T (2010) Effects of Tranexamic Acid on Death, Vascular Occlusive Events, and Blood Transfusion in Trauma Patients with Significant Haemorrhage (CRASH-2): A Randomised, Placebo-Controlled Trial. Lancet, 376, 23-32.

has been cited by the following article:

  • TITLE: Oral Tranexamic Acid in Hip and Knee Arthroplasty: A Prospective Cohort Study

    AUTHORS: Stephen McGrath, Piers Yates, Gareth Prosser

    KEYWORDS: Tranexamic Acid, Blood Loss, Surgical, Blood Conservation Strategy, Total Hip Replacement, Total Knee Replacement

    JOURNAL NAME: Open Journal of Orthopedics, Vol.4 No.8, August 11, 2014

    ABSTRACT: Intravenous Tranexamic acid has been shown to decrease blood transfusion requirements in sur- gery. Little evidence exists regarding the much cheaper oral form. The objective of this cohort study was to evaluate whether oral tranexamic acid administration in patients undergoing elec- tive hip and knee replacement surgery resulted in decreased transfusion requirements. Methods: We assessed the transfusion requirements of 332 patients following unilateral total hip or knee arthroplasty, with the first 140 receiving no tranexamic acid and the next 192 given 1 g oral tranexamic acid one hour prior to and a further 1 g 4 hours post joint arthroplasty. Haemoglobin before and after surgery, the number of units transfused post-operatively and the incidence of deep vein thrombosis or pulmonary embolism were recorded. Results: In the first group, there were 22 instances of transfusion (15.7%) and a mean haemoglobin drop of 32.2 g/L, while the second (tranexamic acid) group had just 12 patients transfused (6.3%) and a mean haemoglobin drop of 24.6 g/L (both significantly less, p