TITLE:
A 10 Years Comparative Study to Assess Trends in Seroprevalence of Transfusion Transmitted Infections among Blood Donors at Gwalior, India
AUTHORS:
Dharmesh Chandra Sharma, Sunita Rai, Savita Bharat, Sudha Iyenger, Shruti Gupta, Bharat Jain
KEYWORDS:
Transfusion Transmitted Infections (TTIs), Blood Donor (BD), Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Syphilis and Malaria
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.4 No.2,
June
27,
2014
ABSTRACT:
Introduction: Transfusion Transmitted Infections (TTIs) threaten safety
of the recipients and the community as a whole and are the subject of real
concern worldwide. Aims and Objectives: To know the prevalence of transfusion
transmitted infections amongst the blood donors, to evaluate the changing
trends of TTIs and to compare these observations within the study as well as
with the other relevant studies. Place and Duration of Study: This study was
carried out at Blood Bank, Department of Pathology, Gajra Raja Medical
College, Gwalior, India, from January 2004 to December 2013 (ten years).
Materials and Methods: In this study 122,006 voluntary and replacement donations
were screened for TTIs; HIV, HBV, HCV, Syphilis, Malaria and their
seroprevalence was calculated. Further study was divided in Group “A” (from
2004 to 2008) and Group “B” (from 2009 to 2013) to compare the results.
Results: Out of total 122,006 blood units collected, 79,750 (65.3%) were
voluntary and 42,256 (34.7%) were replacement donors. The seropositivity of
TTIs in the entire study, in group “A” and in Group “B” was 3.26% (3985/122,006)
(p = 0.000005), 2.25% (1238/54,874) (p = 0.000005) and 4.09% (2747/67,123) (p = 0.000005) respectively. In Group “A”
and “B” seroprevalence of HIV, HBV, HCV, Syphilis and Malaria was 0.29%, 1.16%,
0.61%, 0.06%, 0.11% and 0.13%, 3.15%, 0.24%, 0.17%, 0.03% respectively.
Conclusion: Our study concluded that there was significant increase in
seroprevalence of HBV and syphilis whereas decreasing pattern in HIV, HCV and
Malaria was observed in last five years as compared to previous five years
among the blood donors.