Synthesis and fungicidal activity of some sulphide derivatives of O-phenyl-N-substituted phenylcarbamates
F. E. Adelowo, I. A. O. Ojo, O. S. Amuda
DOI: 10.4236/abc.2011.13015   PDF    HTML     5,956 Downloads   11,197 Views   Citations


Monosulphides of O-phenyl-N-substituted phenylcar- bamates were prepared by the reaction between O- phenyl-N-substituted phenylcarbamates and sulph- ur dichloride while the corresponding disulphides were prepared by the reaction between O-phenyl-N- substituted phenylcarbamates and sulphur monoch- loride. The synthesized compounds were characte-rized by elemental analysis, thin layer chromatogra-phy (TLC), Fourier-transform infrared, 1H and 13C nuclear magnetic resonance spectroscopic techniques. In vitro fungicidal assay of these sulphides against Fusarium oxysporum, Aspergillus niger, Aspergillus flavus and Rhizopus stolonifer showed that they were more fungicidal than their parent carbamates. The synthesized sulphides were more active towards As-pergillus niger and Aspergillus flavus. There was little or no variations in the fungicidal activities of the synthesized monosulphides and disulphides of O-phen- yl-N-substituted phenyl carbamates.

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Adelowo, F. , Ojo, I. and Amuda, O. (2011) Synthesis and fungicidal activity of some sulphide derivatives of O-phenyl-N-substituted phenylcarbamates. Advances in Biological Chemistry, 1, 122-127. doi: 10.4236/abc.2011.13015.

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The authors declare no conflicts of interest.


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