Infantile Hemangiopericytoma: Two Cases Report and Literature Review


Hemangiopericytoma is a rare vascular tumour of infants. Although generally considered to be benign, local recurrence and metastases can occur. Herein, we report on two full term girls, delivered with lumbosacral swelling and left thigh swelling respectively. Complete surgical excision with safety margins was performed for each lesion. Histologic examination of both lesions showed picture of infantile hemangiopericytoma. There is no evidence of local recurrence or distant metastasis during last 20 and 17 months for 1st case and 2nd case respectively. In conclusion; most infantile hemangiopericytoma follow a benign course. Rarely these tumours behave aggressively with local infiltration, recurrences and even distant metastases. Careful follow up is therefore essential.

Share and Cite:

G. Al-Saied, A. Abokifa, M. Al-Saeed, M. Aziz, M. Ibrahim, M. Hafez, T. Hussain, M. Shahin, D. Nemenqani and N. Fawzy, "Infantile Hemangiopericytoma: Two Cases Report and Literature Review," Surgical Science, Vol. 2 No. 7, 2011, pp. 379-384. doi: 10.4236/ss.2011.27083.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] I. Hatzokos, I. Gigis, E. Iosifidou, A. Drakou and J. Pournaras, “Primary Hemangiopericytoma of the Tibia. Treatment by en Bloc Resection and Bone Transportation. A Case Report,” Acta orthopaedica Belgica, Vol. 71, 2005, pp. 122-127.
[2] P. V. Bailey, T. R. Weber, T. F. Tracy, D. M. O’Connor and C. Sotelo-Avila, “Congenital Hemangiopericytoma: an Unusual Vascular Neoplasm of Infancy,” Bottom of Form Surgery, Vol. 114, 1993, pp. 936-941.
[3] M. J. Hahn, R. Dawnson, J. A. Esterly and D. J. Joseph, “Hemangiopericytoma. An Ultrastructural Study,” Cancer, Vol. 31, No1, 1973, pp. 255-261.
[4] S. L. Kauffman and A. P. Stout, “Hemangiopericytoma in Children,” Cancer, Vol. 13, No. 4, 1960, pp. 695-710.
[5] A. P. Stout and M. R. Murray, “Hemangiopericytoma: A Vascular Tumor Featuring Zimmermann’s Pericytes,” Annals of Surgery, Vol. 116, No. 1, 1942, pp. 26-33. doi:10.1097/00000658-194207000-00004
[6] S. A. Hoey, R. M. Letts and C. Jinemez, “Infantile Hemangiopericytoma of the Musculoskeletal System: Case Report and Literature Review,” Journal of Pediatric Orthopaedics, Vol. 18, No. 3, 998, pp. 359-362.
[7] D. L. Baker, D. Oda and R. W. Myall, “Intraoral Infantile Hemangiopericytoma: Literature Review and Addition of a Case,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, Vol. 73, No. 5, 1992, pp. 596-602.
[8] P. Maillet, A. Lamesch and M. P. Dawagne, “Congenital Hemangiopericytoma,” Chiropractic Pediatrics, Vol. 26, 1985, pp. 22-25.
[9] T. M. O’Donnell, A. T. Devitt, S. Kutty and E. E. Fogarty, “Recurrent Congenital Hemangiopericytoma in a Child,” Journal of Bone and Joint Surgery, Vol. 83-B, No. 2, 2001, pp. 269-272.
[10] F. C. Reynolds and W. E. Lansche, “Hemangiopericytoma of the Lower Extremity: A Case Report,” Journal of Bone and Joint Surgery, Vol. 40-A, No. 4, 1958, pp. 921-924.
[11] C. M. Coffin and L. P. Dehner, “Fibroblastic-Myofibroblastic Tumours in Children and Adolescents: A Clinico-Pathologic Study of 108 Examples in 103 Patients,” Pediatric Pathology, Vol. 11, No. 4, 1991, pp. 569-588. doi:10.3109/15513819109064791
[12] H. Isaacs, “Perinatal (Congenital and Neonatal) Neoplasms: A Report of 110 Cases,” Pediatric Pathology, Vol. 3, No. 2-4, 1985, pp. 165-216. doi:10.3109/15513818509078782
[13] T. Mentzel, E. Calonje, A. G. Nascimento and C. D. Fletcher, “Infantile Hemangiopericytoma Versus Infantile Myofibromatosis: Study of a Series Suggesting a Continuous Spectrum of Infantile Myofibroblastic Lesions,” The American Journal of Surgical Pathology, Vol. 18, No. 9, 1994, pp. 922-930. doi:10.1097/00000478-199409000-00007
[14] J. B. Atkinson, G. H. Mahour, H. Isaacs Jr. and J. A. Ortega, “Hemangiopericytoma in Infants and Children: A Report of Six Patients,” American Journal of Surgery, Vol. 148, No. 3, 1984, pp. 372-374. doi:10.1016/0002-9610(84)90474-4
[15] P. V. Bailey, T. R. Weber, T. F. Tracy, D. M. O’Connor and C. Sotelo-Avila, “Congenital Hemangiopericytoma: An Unusual Vascular Neoplasm of Infancy,” Surgery, Vol. 114, 1993, pp. 936-941.
[16] J. P. Craven, T. M. Quigley, J. W. Bolen and E. J. Raker, “Current Management and Clinical Outcome of Hemangiopericytomas,” American Journal of Surgery, Vol. 163, No. 5, 1992, pp. 490-493. doi:10.1016/0002-9610(92)90394-7
[17] H. Battifora, “Hemangiopericytoma: Ultrastructural Study of Five Cases,” Cancer, Vol. 31, 1973, pp. 1418-1432.
[18] J. G. Mira, F. C. Chu and J. G. Fortner, “The Role of Radiotherapy in the Management of Malignant Hemangiopericytoma: A Report of Eleven New Cases and a Review of the Literature,” Cancer, Vol. 39, 1977, pp. 1254-1259.
[19] S. Variend, M. Bax and J. van Gorp, “Are Infantile Myofibromatosis, Congenital Fibrosarcoma, and Congenital Hemangiopericytoma Histogenetically Related?” Histopathology, Vol. 26, 1995, pp. 57-62.
[20] P. P. Wong and A. Yagoda, “Chemotherapy of Malignant Hemangiopericytoma,” Cancer, Vol. 41, 1978, pp. 1256-1260.
[21] N. Jha, M. McNeese, H. T. Barkley and J. Kong, “Does Radiotherapy Have a Role in Hemangiopericytoma Management? Report of 14 New Cases and a Review of the Literature,” International Journal of Radiation Oncology ? Biology ? Physics, Vol. 13, No. 9, 1987, pp. 1399-1402.
[22] M. F. Borg and C. S. Benjamin, “A 20 Year Review Of Hemangiopericytoma in Auckland, New Zealand,” Clinical oncology (Royal College of Radiologists, Vol. 6, 1994; pp. 371-376.
[23] J. J. Seibert, R. W. Seibert, D. S. Weisenburger and W. Allsbrook, “Multiple Congenital Hemangiopericytomas of the Head and Neck,” Laryngoscope, Vol. 88, 1978, pp. 1006-1012.
[24] A. Morgan and I. Evbuomwan, “Congenital Hemangiopericytoma of the Face with Early Distant Metastasis,” Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, Vol. 28, 1983, pp. 123-125.
[25] E. Salloum, F. Flamant, J. M. Caillaud, et al., “Diagnostic and Therapeutic Problems of Soft Tissue Tumours Other than Rhabdomyosarcoma in Infants under 1 Year of Age: A Clinicopathological Study of 34 Cases Treated at the Institut Gustave-Roussy,” Medical and Pediatric Oncology, Vol. 18, 1990, pp. 37-43. doi:10.1002/mpo.2950180108

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.