Smoking Cessation with E-Cigarettes in Smokers with a Documented History of Depression and Recurring Relapses


The association between nicotine dependence and affective disorders, particularly major depressive disorder (MDD), is well known with high prevalence rates being reported for smokers. The reason for this association is not clear, but, it has been argued that smoking may help individuals to cope with stress or medicate depressed mood. Smoking cessation programs are useful in helping smokers to quit, but smoking is a very difficult addiction to break, especially for people suffering from depression, and the need for novel and effective approaches to smoking cessation interventions for this special population is unquestionable. The e-cigarette is a battery-powered electronic nicotine delivery device (ENDD), which may help smokers to remain abstinent during their quit attempt. Here, we report for the first time objective measures of smoking cessation in two heavy smokers, suffering from depression, who experimented the e-cigarette.

Share and Cite:

P. Caponnetto, R. Polosa, R. Auditore, C. Russo and D. Campagna, "Smoking Cessation with E-Cigarettes in Smokers with a Documented History of Depression and Recurring Relapses," International Journal of Clinical Medicine, Vol. 2 No. 3, 2011, pp. 281-284. doi: 10.4236/ijcm.2011.23046.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years’ observations on male British doctors. BMJ. 2004 Feb 14; 328(7436): 1519-28.
[2] Boyle, P., Gray, N., Henningfield, J., Seffrin, J., and Zatonski, W. (2004) Tobacco and Public Health: Science and Policy. Oxford University Press: Oxford.
[3] US Department of Health and Human Services. The health benefits of smoking cessation (DHHS Publication No. (CDC) 90-8516). USA, US Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 1990.
[4] Lightwood JM, Glantz SA. Short-term economic and health benefits of smoking cessation. Circulation 1997; 96: 1089-96.
[5] Fiore MC, Jaen CR, Baker TB, Bailey WC, Benowitz N, Curry SJ, et al. Treating tobacco use and dependence: 2008 update. US Dept of Health and Human Services, Public Health Service; May 2008.
[6] Breslau, N., Kilbey, M., & Andreski, P. Nicotine de- pendence and major depression. Arch Gen Psychiatry 1993; 50: 31-5.
[7] Anda RF, Williamson DF, Escobedo LG, Mast EE, Giovino GA, Remington PL. Depression and the dynamics of smoking. JAMA 1990; 264: 1541-5.
[8] Revell, A. D., Warburton, D. M., & Wesnes, K. Smoking as a coping strategy. Addict Behav 1985; 10 (3): 209-24.
[9] Covey LS, Glassman AH, Stetner F. Major depression following smoking cessation. Am. J. Psychiatry 1997; 154(2): 263-5.
[10] Glassman AH. Cigarette smoking: implications for psychiatric illness. Am J Psychiatry 1993; 150(4): 546-53.
[11] Caponnetto P., Polosa R. Common predictors of smoking cessation in clinical practice. Respir. Med. 2008 Aug; 150(4): 546-53
[12] Hitsman B, Borrelli B, McChargue DE, Spring B, Niaura R. History of Depression and Smoking Cessation Out- come: A Meta-Analysis. JCCP 2003; 71(4): 657-663.
[13] Kinnunen T, Haukkala A, Korhonen T, Quiles ZN, Spiro A, Garvey AJ. Depression and smoking across 25 years of the Normative Aging Study. Int J Psychiatry Med 2006; 36(4): 413-26.
[14] Casella G, Caponnetto P, Polosa R. Therapeutic advances in the treatment of nicotine addiction: Present and Future. Sept. 1, 2010; 1(3): 95-106.
[15] Piccillo G, Caponnetto P, Barton S, Russo C, Origlio A, Bonaccorsi A, Di Maria A, Oliveri C, Polosa R. Changes in airway hyperresponsiveness following smoking cessa- tion: comparisons between Mch and AMP. Respir Med. 2008; 102(2): 256-65.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.