Fanconi anemia manifesting as a squamous cell carcinoma of the mandible: a case report
A. Pinar Erdem, G. Ikikarakayali, N. Yalman, G Ak, M. A Erdem, M. B. Bilgic, E. Sepet
DOI: 10.4236/ojst.2011.12008   PDF    HTML     4,402 Downloads   8,363 Views  

Abstract

Progressive bone marrow failure and development of malignancies, particularly acute myeloid leukemia and solid tumors the most important features of Fan- coni’s Anemia (FA). This paper reports the case of a 16-year-old patient with FA who developped squa- mous cell carcinoma of the mandible, ten years after the bone marrow transplantation (BMT).

Share and Cite:

Erdem, A. , Ikikarakayali, G. , Yalman, N. , Ak, G. , Erdem, M. , Bilgic, M. and Sepet, E. (2011) Fanconi anemia manifesting as a squamous cell carcinoma of the mandible: a case report. Open Journal of Stomatology, 1, 45-49. doi: 10.4236/ojst.2011.12008.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Oksüzo?lu, B., Yal?in, S. Ann Hematol. (May 2002) 81, 294-298. Epub 2002 May 3. doi:10.1007/s00277-002-0455-6
[2] Somers, G.R., Tabrizi, S.N., Tiedemann, K., Chow, C.W., Garland, S.M., Venter, D.J. (July-August 1995) Pediatric Pathology & Laboratory Medicine, 15, 597-607.
[3] Kutler, D.I., Auerbach, A.D., Satagopan, J., Giampietro, P.F., Batish, S.D., Huvos, A.G., Goberdhan, A., Shah, J.P. and Singh, B. (January 2003) High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia Archives of Otolaryngology-Head & Neck Surgery, 129, 106-112. doi:10.1001/archotol.129.1.106
[4] Alter, B.P. 1996 Fanconi’s anemia and malignancies. American Journal of Hematology, 53, 99-110. doi:10.1002/(SICI)1096-8652(199610)53:2<99::AID-AJH7>3.0.CO;2-Z
[5] Salum, F.G., Martins, G.B,, de Figueiredo, M.A., Che- rubini, K., Yurgel, L.S. and Torres-Pereira, C. (2006) Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia. Brazilian Dental Journal, 17, 161-165. doi:10.1590/S0103-64402006000200015
[6] Alter, B.P. (2003) Cancer in Fanconi anemia, 1927–2001. Cancer, 97, 425-440. doi:10.1002/cncr.11046
[7] Rosenberg, P.S,, Grene, M.H. and Alter, B.P. (2003) Cancer incidence in persons with Fanconi anemia. Blood, 101, 822-826. doi:10.1182/blood-2002-05-1498
[8] Auerbach, A.D., Rogatko, A. and Schroeder-Kurth, T.M. (1989) International fanconi anemia registry: Relation of clinical symptoms to diepoxybutane sensitivity. Blood, 73, 391-396.
[9] Joenje, H., Levitus, M., Waisfisz, Q., et al. (2000) Complementation analysis in Fanconi anemia: Assign- ment of the reference FA-H patient to group A. American Journal of Human Genetics, 67, 759-762. doi:10.1086/303067
[10] Timmers, C., Taniguchi, T., Hejna, J., et al. (2001) Positional cloning of a novel Fanconi anemia gene, FANCD2. Molecular Cell, 7, 241-248. doi:10.1016/S1097-2765(01)00172-1
[11] Linares, M., Pastor, E., Gomez, A. and Grau, E. (1991) Hepatocelluler carcinoma and squamous cell carcinoma in a patient with Fanconi’s anemia. Annals of Hema- tology, 63, 54-55. doi:10.1007/BF01714963
[12] Moldvay, J., Schaff, Z., Lapis, K. (1991) Hepatocellular carcinoma in Fanconi’s anemia treated with androgen and corticosteroid. Zentralblatt fur Pathologie, 137, 167-170.
[13] Reed, K., Ravikumar, T.S., Gifford, R.R., Grage, T.B. (1983) The association of Fanconi’s anemia and Squa- mous cell carcinoma. Cancer, 52, 926-928. doi:10.1002/1097-0142(19830901)52:5<926::AID-CNCR2820520530>3.0.CO;2-T
[14] Kennedy, A.W., Hart, W.R. (1982) Multiple squamous cell carcinomas in Fanconi’anemia. Cancer, 50, 811-814. doi:10.1002/1097-0142(19820815)50:4<811::AID-CNCR2820500432>3.0.CO;2-I
[15] Lustig, J.P., Lugassy, G., Neder, A. and Sigler, E. (1995) Head and neck carcinoma in fanconi’s anemia-report of a case and review of the literature. European Journal of Cancer Part B: Oral Oncology, 31, 68-72. doi:10.1016/0964-1955(94)00044-5
[16] Jansisyanont, P., Pazoki, A. and Ord, R.A. (2000) Squamous cell carcinoma of the tongue after bone marrow transplantation in a patiant with Fanconi’s ane- mia. Journal of Oral and Maxillofacial Surgery, 58, 1454-1457. doi:10.1053/joms.2000.19212
[17] Socie, G., Scieux, C., Gluckman, E., Soussi, T., Clavel, C., Saulnier. P., Birembault, P., Bosq, J., Morinet, F. and Janin, A. (1998) Squamous cell carcinoma after allogenic bone marrow transplantation for aplastic anemia: Further evidence of a multistep process. Transplantation, 66, 667-670. doi:10.1097/00007890-199809150-00023
[18] Millen, F.J., Rainey, M.G., Hows, J.M., Burton, P.A,, Irvine, G.H. and Swirsky. D. (1997) Oral squamous cell carcinoma after allogenic bone marrow transplantation for Fanconi anemia. British Journal of Haematology, 99, 410-414. doi:10.1046/j.1365-2141.1997.3683184.x
[19] Bradford, C.R., Hoffman, H.T., Wolf, G.T., Carey, T.E., Baker, S.R. and McClatchey, K.D. (1990) Squamous cell carcinoma of the head and neck in organ transplant recipients: Possible role of oncogenic viruses, The Laryn- goscope, 100, 190-194.
[20] Socie, G., Henry-Amar, M., Cosset, J.M., Devergie, A., Girinsky, T. and Gluckman, E. (1991), Increased ince- dence of solid malignant tumors after bone marrow trans- plantation for sever aplastic anemia. 78, 277-279.
[21] Spardy, N., Duensing, A., Charles, D., Haines, N., Nakahara, T., Lambert, P.F., Duensing, S. (December 2007) The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. The Journal of Virology, 81, 13265-13270. doi:10.1128/JVI.01121-07
[22] Gillison, M.L. and Lowy, D.R. (2004) A casual role for human papillomavirus in head and neck cancer. The Lancet, 363, 1488-1489. doi:10.1016/S0140-6736(04)16194-1
[23] Hermsen, M.A., Xie, Y., Rooimans, M.A., Meijer, G.A., Baak, J.P., Plukker, J.T., Arwert, F. and Joenje, H. (2001) Cytogenetic characteristics of oral squamous cell carcinomas in Fanconi anemia. Familial Cancer, 1, 39-43. doi:10.1023/A:1011528310346

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.