Chondrosarcoma of the Hand: A Literature Review


Chondrosarcoma (CS) is a malignant neoplasm of mesenchymal origin characterized by the formation of cartilaginous matrix by neoplastic cells. It is very variable in presentation, clinical, genetic and anatomo-pathological features. CS is more often found in the pelvis and the proximal long bones (femur, humerus). Localization to the small bones of the hand is very rare and it represents a diagnostic and therapeutic challenge. CSs are malignancies resistant to both radiation and chemotherapy . Surgical treatment is the only mean available. As opposed to CSs located elsewhere, CS of the hand is characterized by local recurrence and very low metastatic potential. In order to definitely set a diagnosis of chondrosarcoma in this region, comparison of histological and radiological findings is paramount. The principle goal of surgery shall be minimizing functional impairment. This provides the rationale for performing curettage, local adjuvant therapy and bone grafting in low-grade lesions.

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Stomeo, D. , Tulli, A. , Ziranu, A. , Mariotti, F. and Maccauro, G. (2014) Chondrosarcoma of the Hand: A Literature Review. Journal of Cancer Therapy, 5, 403-409. doi: 10.4236/jct.2014.54046.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Eriksson, A.I., Schiller, A. and Mankin, H.J. (1980) The Management of Chondrosarcoma of Bone. Clinical Orthopaedics and Related Research, 153, 44-66.
[2] Bertoni, F., Bacchini, P. and Hogendoorn, P.C.W. (2002) Chondrosarcoma. In: Fletcher, C.D.M., Unni, K.K. and Mertens, F., Eds., World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press, Lyon, 247-251.
[3] Miyawaki, T., Kinoshita, Y. and Iizuka, T. (1997) A Case of Ollier’s Disease of the Hand. Annals of Plastic Surgery, 38, 77-80.
[4] Mittermayer, F., Dominkus, M., Krepler, P., Schwameis, E., Sluga, M., Toma, C., Lang, S., Grampp, S. and Kotz, R. (2004) Chondrosarcoma of the Hand: Is a Wide Surgical Resection Necessary? Clinical Orthopaedics and Related Research, 424, 211-215. 10.1097/ 01.blo.00001291 64.91760.95
[5] Bovee, J.V., Van der Heul, R.O., Taminiau, A.H. and Hogendoorn, P.C. (1999) Chondrosarcoma of the Phalanx: A Locally Aggressive Lesion with Minimal Metastatic Potential: A Report of 35 Cases and a Review of the Literature. Cancer, 86, 1724-1732. (19991101)86:9<1724::AID-CNCR14>3.0.CO;2-I
[6] Mankin, H.J. (1999) Chondrosarcomas of Digits: Are They Really Malignant? Cancer, 86, 1635-1637.<1635::AID-CNCR3>3.0.CO;2-#
[7] Aprin, H., Riseborough, E.J. and Hall, J.E. (1982) Chondrosarcoma in Children and Adolescents. Clinical Orthopaedics and Related Research, 166, 226-232.
[8] Shmookler, B., Bickels, J., Jelinek, J., Sugarbaker, P. and Malawer, M. (2001) Bone and Soft-Tissue Sarcomas: Epidemiology, Radiology, Pathology and Fundamentals of Surgical Treatment. Musculoskeletal Cancer Surgery. Springer, The Netherlands, 3-35.
[9] Nigrisoli, M., Ferraro, A., De Cristofaro, R. and Picci, P. (1990) Chondrosarcoma of the Hand and Foot. La Chirurgia degli Organi di Movimento, 75, 315-323.
[10] Unni, K.K. (1996) Chondrosarcoma (Primary, Secondary, Dedifferentiated, and Clear Cell). In: Dahlin’s Bone Tumors. General Aspects and Data on 11,087 Cases. 5th Edition, Lippincott-Raven, Philadelphia, 71-108.
[11] Tos, P., Artiaco, S., Linari, A. and Battiston, B. (2009) Chondrosarcoma in the Distal Phalanx of Index Finger: Clinical Report and Literature Review. Chirurgie de la Main, 28, 265-269.
[12] Greenspan, A., Jundt, G. and Remagen, W. (2007) Cartilage (Chondrogenic) Lesions. In: Differential Diagnosis in Orthopaedic Oncology. Lippincott Williams & Wilkins, Philadelphia.
[13] Evans, H.L., Ayala, A.G. and Romsdahl, M.M. (1977) Prognostic Factors in Chondrosarcoma of Bone: A Clinicopathologic Analysis with Emphasis on Histologic Grading. Cancer, 40, 818-831.<818::AID-CNCR2820400234>3.0.CO;2-B
[14] Ricciardella, M.L., Rossi, E.D., Fadda, G., Graci, C., Spinelli, M.S., Falcone, G., Rosa, M.A. and Maccauro, G. (2011) Angiogenesis in Hand Chondroma: An Immunohistochemical Study. International Journal of Immunopathology and Pharmacology, 24, 143-147.
[15] Folkman, J. (1990) What Is the Evidence That Tumors Are Angiogenesis Dependent? Journal of the National Cancer Institute, 82, 4-6.
[16] Roberts, P.H. and Price, C.H. (1977) Chondrosarcoma of the Bones of the Hand. Journal of Bone & Joint Surgery, 59, 213-221.
[17] Gohla, T., Van Schoonhoven, J., Prommersberger, K.J. and Lanz, U. (2004) Chondrosarcomas of the Hand. Handchir Mikrochir Plast Chir, 36, 328-332.
[18] Goto, T., Motoi, T., Komiya, K., Motoi, N., Okuma. T., Okazaki, H., Takatori, Y., Tange, T. and Nakamura, K. (2003) Chondrosarcoma of the Hand Secondary to Multiple Enchondromatosis; Report of Two Cases. Archives of Orthopaedic and Trauma Surgery, 123, 42-47.
[19] Ramirez-Bollas, J., Padilla-Rosciano, A., Romero-Y, H.A., Lavin-Lozano, A.J., Medina-Castro, J.M., Dubon-Garcia, E. and Turcios-Cadenas, E.R. (2005) Maffucci’s Syndrome. Case Reports and Literature Review. Cir Cir, 73, 217-221.
[20] Aisen, A.M., Martel, W., Braunstein, E.M., McMillin, K.I., Phillips, W.A. and Kling, T.F. (1986) MRI and CT Evaluation of Primary Bone and Soft-Tissue Tumors. American Journal of Roentgenology, 146, 749-756.
[21] Feldman, F., Van Heertum, R., Saxena, C. and Parisien, M. (2005) 18FDG-PET Applications for Cartilage Neoplasms. Skeletal Radiology, 34, 367-374.
[22] Bohndorf, K., Reiser, M., Lochner, B., Feaux de Lacroix, W. and Steinbrich, W. (1986) Magnetic Resonance Imaging of Primary Tumours and Tumour-Like Lesions of Bone. Skeletal Radiology, 15, 511-517.
[23] Hudson, T.M., Hamlin, D.J., Enneking, W.F. and Pettersson, H. (1985) Magnetic Resonance Imaging of Bone and Soft Tissue Tumors: Early Experience in 31 Patients Compared with Computed Tomography. Skeletal Radiology, 13, 134-146.
[24] Pettersson, H., Gillespy, T., Hamlin, D.J., Enneking, W.F., Springfield, D.S., Andrew, E.R., Spanier, S. and Slone, R. (1987) Primary Musculoskeletal Tumors: Examination with MR Imaging Compared with Conventional Modalities. Radiology, 164, 237-241.
[25] Ogose, A., Unni, K.K., Swee, R.G., May, G.K., Rowland, C.M. and Sim, F.H. (1997) Chondrosarcoma of Small Bones of the Hands and Feet. Cancer, 80, 50-59.<50::AID-CNCR7>3.0.CO;2-J
[26] Cawte, T.G., Steiner, G.C., Beltran, J. and Dorfman, H.D. (1982) Chondrosarcoma of the Short Tubular Bones of the Hands and Feet. Skeletal Radiology, 27, 625-632.
[27] Floyd, W.E. and Troum, S. (1995) Benign Cartilaginous Lesions of the Upper Extremity. Hand Clinics, 11, 119-132.
[28] Rinas, A.C., Ward, W.G. and Kilpatrick, S.E. (2005) Potential Sampling Error in Fine Needle Aspiration Biopsy of Dedifferentiated Chondrosarcoma: A Report of 4 Cases. Acta Cytologica, 49, 554-559.
[29] Jennings, R., Riley, N., Rose, B., Rossi, R., Skinner, J.A., Cannon, S.R., Briggs, T.W., Pollock, R. and Saifuddin, A. (2010) An Evaluation of the Diagnostic Accuracy of the Grade of Preoperative Biopsy Compared to Surgical Excision in Chondrosarcoma of the Long Bones. International Journal of Surgical Oncology, 2010, Article ID: 270195.
[30] Takigawa, K. (1971) Chondroma of the Bones of the Hand. A Review of 110 Cases. Journal of Bone and Joint Surgery, American Volume, 53, 1591-1600.
[31] Gitelis, S., Bertoni, F., Picci, P. and Campanacci, M. (1981) Chondrosarcoma of Bone. The Experience at the Istituto Ortopedico Rizzoli. Journal of Bone and Joint Surgery, American Volume, 63, 1248-1257.
[32] Falcone, G., Rossi, E.D., Maccauro, G., de Santis, V., Rosa, M.A., Capelli, A. and Fadda, G. (2006) Diagnostic Relevance of the Immunohistochemical Detection of Growth Factors in Benign and Malignant Cartilaginous Tumors. Applied Immunohistochemistry & Molecular Morphology, 14, 334-340.
[33] Hatori, M., Watanabe, M., Kotake, H. and Kokubun, S. (2006) Chondrosarcoma of the Ring Finger: A Case Report and Review of the Literature. The Tohoku Journal of Experimental Medicine, 208, 275-281.
[34] Exner, G.U., Dumont, C.E., Malinin, T.I. and von Hochstetter, A.R. (2003) Recurrent Aggressive Chondrosarcoma of the Middle Phalanx of the Index Finger: Excision and Reconstruction with an Osteocartilaginous Allograft. Archives of Orthopaedic and Trauma Surgery, 123, 425-428.

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