Prevalence of Human Leukocyte Antigen HLA-B*5701 in HIV-1 Infected Individuals in Brazil

Claudinéia de Araújo^1*, Cristina Valetta de Carvalho¹, Miriam Estela de Souza Freire², Amanda Yamaguti³, Ivens Cuiabano Scaff⁴, Fernando José de Souza⁵, Flávia Galindo Silvestre Silva⁵, Ricardo Sobhie Diaz¹, Ismael Dale Cotrim Guerreiro da Silva¹

¹Department of Gynecology, Molecular Gynecology Laboratory, Federal University of São Paulo, São Paulo, Brazil.
²State Department of Health of Mato Grosso, Cuiabá, Brazil.
³Unirondon University, Cuiabá, Brazil.
⁴Infectious Diseases Division, Federal University of Mato Grosso, Cuiabá, Brazil.
⁵Imunogenetics Laboratory, General University Hospital, Cuiabá, Brazil.

DOI: 10.4236/ojgen.2014.41008                

Abstract

This study was designed to establish the prevalence of HLA-B*5701 at HIV-1 infected individuals in Brazil. A total of 517 consecutive individuals were followed in this study from February 2009 through July 2011. The presence of HLA-B*5701 was determined by Nested-PCR with HLA-B*57 and HLA-B*5701 sequence-specific primers (PCR-SSP). The expression of HLA-B*57 was negative in the 385 (74.5%) and positive in the 103 (19.9%) of infected individuals. Among these, the expression of HLA-B5701 was positive in the 29 (5.6%) of individuals. No demographic or ethnic differences were found between HLA-B*57/HLA-B*5701 HIV-1 negative patients, with a prevalence of Caucasians (57.1%) individuals. During the period of study, 68 patients were submited to an abacavir contain- ing regimen. The HLA-B*5701 allele was observed in 7 (10.3%) patients, with a significant incidence of Hypersensitivity reactions at 4 of them (p < 0.001). Conclusions: Although Brazilian population consists of a mixture of individuals of Caucasian, African and Native American genetic background, prevalence of HLA-B*5701 in this population is similar to the one found in pure Caucasians.

Keywords

Immunogenetics; Human Immunodeficiency Virus; HLA-B*5701 Antigen Human; Abacavir

Conflicts of Interest

The authors declare no conflicts of interest.

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