Stepwise Confidence Interval Method for MTD Studies with Binomial Populations

Na Yu, Xiaoqing Tang, Hanxing Wang

Department of Mathematics and Physics, Shanghai University of Electric Power, Shanghai, China.
Department of Mathematics and Physics, Shanghai University of Electric Power, Shanghai, China Department of Mathematics and Physics, Shanghai University of Electric Power, Shanghai, China.
School of Mathematics & Information, Shanghai Lixin University of Commerce, Shanghai, China.

DOI: 10.4236/eng.2013.510B095                

Abstract

Now we extend one method into a sequence of binomial data, propose a stepwise confidence interval method for toxic-ity study, and also in our paper, two methods of constructing intervals for the risk difference are proposed. The first one is based on the well-known conditional confidence intervals for odds ratio, and the other one comes from Santner“small-sample confidence intervals for the difference of two success probabilities”, and it produces exact intervals, through employing our method.

Keywords

Stepwise Confidence Interval; Practical Equivalence; Maximum Tolerated Dose

Conflicts of Interest

The authors declare no conflicts of interest.

References

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