Hybrid ameloblastoma in a nigerian: Report of a case and review of literature

O. A. Effiom, O. James, O. T. Akeju, A. S. Salami, O. Odukoya

Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Lagos, Nigeria.
Department of Oral Pathology and Oral Biology, College of Medicine, University of Lagos, Lagos University Teaching Hospital, Lagos, Nigeria.
Department of Oral Pathology and Oral Biology, Lagos University Teaching Hospital, Lagos, Nigeria.

DOI: 10.4236/ojst.2013.37059                

Abstract

Background: Hybrid Ameloblastoma is a rare type of ameloblastoma that is presently receiving attention in some quarters. Altogether, less than 30 cases have been reported in the scientific literature, thus calling for the need to report more cases in order to add to the body of knowledge on this lesion. This case report is aimed to add to the number of cases that are building up in the scientific literature. Materials and Methods: A 50-year-old female presented with a 3-year history of an anterior mandibular swelling extending from the body of the mandible on the right to the body of the mandible on the left. Orthopantomograph of the lesion revealed a mixed radiolucent and radiopaque lesion that extended from the distal region of the right mandibular second premolar to distal region of the left mandibular second molar. Segmental mandibulectomy with immediate replacement with reconstruction was undertaken. Results: Specimen which was subjected to histopathologic examination reported a diagnosis of Keratinizing Follicular Ameloblastoma and Desmoplastic Ameloblastoma with Osteoplasia, consistent with a diagnosis of Hybrid Ameloblastoma. There has been no sign of recurrence 7 months after a regular follow-up and the patient is planned for a long term follow-up. Conclusion: Besides histological details that combine both conventional ameloblastoma and desmoplastic ameloblastoma, the present case of hybrid ameloblastoma bears similar clinical features as well as treatment modalities to that of conventional solid multicystic ameloblastoma.

Keywords

Ameloblastoma; Hybrid; Nigerian

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Barnes, L, Eveson, J.W., Reichart, P. and Sidransky, D. (2005) World Health Organization classification of tumours pathology and genetics of head and neck tumours. IARC Press, Lyon, 283-328.
[2]	Dandriyal, R., Gupta, A., Pant, S. and Baweja, H. H. (2011) Surgical management of ameloblastoma: Conservative or radical approach. National Journal of Maxillofacial Surgery, 2, 22-27. http://dx.doi.org/10.4103/0975-5950.85849
[3]	Gnepp, D.R. (2009). Diagnostic surgical sathology of the head and neck. 2nd Edition, Saunders, Philadelphia, 785-838.
[4]	Gardner, D.G. (1996) Some current concepts on the pathology of ameloblastomas. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics, 82, 660-669. http://dx.doi.org/10.1016/S1079-2104(96)80441-0
[5]	Gomes, C.C., Duarte, A.P., Diniz, M.G. and Gomez, R.S. (2010) Review article: Current concepts of ameloblastoma pathogenesis. Journal of Oral Pathology & Medicine, 39, 585-591. http://dx.doi.org/10.1111/j.1600-0714.2010.00908.x
[6]	Buchner, A. and Carpenter, W.M. (2006) Relative frequency of central odontogenic tumors: A study of 1,088 cases from Northern California and comparison to studies from other parts of the world. Journal of Oral and Maxillofacial Surgery, 64, 1343-1352. http://dx.doi.org/10.1016/j.joms.2006.05.019
[7]	Lu, Y., Xuan, M., Takata, T., Wang, C., He, Z., Zhou, Z., Mock, D., et al. (1998) Odontogenic tumors: A demographic study of 759 cases in a Chinese population. Oral Surgery, Oral Medicine, Oral Pathology, 86, 707-714. http://dx.doi.org/10.1016/S1079-2104(98)90208-6
[8]	Adebayo, E.T., Ajike, S.O. and Adekeye, E.O. (2005). A review of 318 odontogenic tumors in Kaduna, Nigeria. Journal of Oral and Maxillofacial Surgery, 63, 811-819. http://dx.doi.org/10.1016/j.joms.2004.03.022
[9]	Adebiyi, K.E., Ugboko, V.I., Omoniyi-Esan, G.O., Ndukwe, K.C. and Oginni, F.O. (2006) Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head & Face Medicine, 2, 42-46. http://dx.doi.org/10.1186/1746-160X-2-42
[10]	Li., W.L., Liu., F.Y., Xu., Z.F., Huang, S.H., Zhu., W., and Sun, C.F. (2012) Treatment of ameloblastoma in children and adolescents. Journal of Hard Tissue Biology, 21, 121-126.
[11]	Ladehinde, A.L., Ogunlewe, M.O., Bamgbose, B.O., Lanre, W.L., Ajayi, O.F., Arotiba, G.T. and Akinwande, J.A. (2006) Ameloblastoma: Analysis of 207 cases in a Nigerian teaching hospital. Quintessence International, 37, 69-74.
[12]	Hertog, D., Bloemena, E., Aartman, I.H.A., van der Waal, I. (2012) Histopathology of ameloblastoma of the jaws; Some critical observations based on a 40 years single institution experience. Medicina Oral, Patología Oral y Cirugía Bucal, 17, e76-82. http://dx.doi.org/10.4317/medoral.18006
[13]	Harsha, B.G., Ingle, E., Dornadula, K., Saraswathi, G. (2011) Hybrid lesion of desmoplastic and conventional ameloblastoma—A case report. Journal of International Oral Health, 3, 43-47.
[14]	Waldron, C.A., EL-Mofty, S.K. (1987) A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant. Oral Surgery, Oral Medicine, Oral Pathology, 63, 441-451. http://dx.doi.org/10.1016/0030-4220(87)90257-X
[15]	Philipsen, H.P., Reichart, P.A. and Takata, T. (2001) Desmoplastic ameloblastoma (including “hybrid” lesion of ameloblastoma). Biologic profile based on 100 cases from the literature and own files. Oral Oncology, 37, 455-460. http://dx.doi.org/10.1016/S1368-8375(00)00111-1
[16]	Philipsen, H.P., Ormiston, I.W. and Reichart, P.A. (1992) The desmo-and osteoplastic ameloblastoma. Histologic variant or clinicopathologic entity? Case reports. International Journal of Oral and Maxillofacial Surgery, 21, 352-357. http://dx.doi.org/10.1016/S0901-5027(05)80761-1
[17]	Gupta, A. and Jindal, C. (2011) Hybrid ameloblastoma: report of a rare case and review of literature. International Journal of Oral and Maxillofacial Surgery, 2, 68-72
[18]	Lawal, A.O., Adisa, A.O., Olusanya, A.A. and Adeyemi, B.F. (2011) “Hybrid” ameloblastoma: A report of two cases. African Journal of Medicine & Medical Sciences, 40, 11-13
[19]	Effiom, O.A. and Odukoya, O. (2011) Desmoplastic ameloblastoma: Analysis of 17 Nigerian cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics, 111, e27-31. http://dx.doi.org/10.1016/j.tripleo.2010.06.021
[20]	dos Santos, J.N., De Souza, V.F., Azevêdo, R.A., Sarmento, V.A. and Souza, L.B. (2006) “Hybrid” lesion of desmoplastic and conventional ameloblastoma: Immunohistochemical aspects. Brazilian Journal of Otorhinolaryngology, 72, 709-713.
[21]	Yazdi, I., Seyedmajidi, M. and Foroughi, R. (2009) Desmoplastic ameloblastoma (a hybrid variant): Report of a case and review of the literature. Archives of Iranian Medicine, 12, 304-308.
[22]	Takata, T., Miyauchi, M., Ogawa, I., et al. (1999) So called “hybrid” lesion of desmoplastic and conventional ameloblastoma: Report of a case and review of literature. Pathology International, 49, 1014-1018. http://dx.doi.org/10.1046/j.1440-1827.1999.00972.x
[23]	Melrose, R.J. (1999) Desmoplastic ameloblastoma. Pathology Review, 4, 21-27