Relationship between food polyamines and gross domestic product in association with longevity in Asian countries


The relationship between gross domestic pro- duct (GDP) and dietary profile, with a focus on polyamine intake, was investigated in 35 Asian countries. Data on food supply, GDP, and health condition were collected from databases of the United Nations, the International Monetary Fund, and the World Health Organization, respectively. The amount of polyamine intake from food was estimated using polyamine concentrations listed in published sources. The amounts of putrescine, spermidine, spermine, and total polyamines in 1000 kcal of food in Asian countries were 39.07 ± 17.98, 33.74 ± 14.35, 14.05 ± 6.60 and 86.85 ± 33.96 μmol/1000 kcal, respectively. Putrescine, spermidine, and spermine constituted 44, 39, and 17% of total polyamine, respectively. Vegetables contributed the largest amount of both putrescine and spermidine and the second largest amount of spermine (45.5%, 62.2% and 27.2% of total putrescine, spermidine, and spermine, respectively). Meat was the richest source of spermine and contributed the greatest amount (50%) of this polyamine. We showed a significant positive association between GDP and the amount of polyamine per 1000 kcal of food. Lifespan was associated with both GDP and the amount of polyamine per energy quotient of food. As several basic research studies have shown that polyamines help prolong longevity, it follows that polyamines may have a role in determining the lifespan of humans.

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Binh, P. , Soda, K. , Maruyama, C. and Kawakami, M. (2010) Relationship between food polyamines and gross domestic product in association with longevity in Asian countries. Health, 2, 1390-1396. doi: 10.4236/health.2010.212206.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Eisenberg, T., Knauer, H., Schauer, A., Buttner, S., Ruckenstuhl, C., Carmona-Gutierrez, D., Ring, J., Schroeder, S., Magnes, C., Antonacci, L., Fussi, H., Deszcz, L., Hartl, R., Schraml, E., Criollo, A., Megalou, E., Weiskopf, D., Laun, P., Heeren, G., Breitenbach, M., Grubeck-Loebenstein, B., Herker, E., Fahrenkrog, B., Frohlich, K.U., Sinner, F., Tavernarakis, N., Minois, N., Kroemer, G. and Madeo, F. (2009) Induction of autopha-gy by spermidine promotes longevity. Nature Cell Biology, 11, 1305-1314.
[2] Soda, K., Dobashi, Y., Kano, Y., Tsujinaka, S. and Koni-shi, F. (2009) Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Experimental Gerontology, 44, 727-732.
[3] Quemener, V., Chamaillard, L., Brachet, P., Havouis, R. and Moulinoux, J.P. (1994) Involvement of polyamines in malignant proliferative processes: antineoplastic effects of a polyamine deficiency. Bulletin de l'Academie Nationale de Medecine, 178, 1591-1605.
[4] Quemener, V., Blanchard, Y., Chamaillard, L., Havouis, R., Cipolla, B. and Moulinoux, J.P. (1994) Polyamine deprivation: A new tool in cancer treatment. Anticancer Research, 14, 443-448.
[5] Pegg, A.E. (1988) Polyamine metabolism and its impor-tance in neoplastic growth and a target for chemotherapy. Cancer Research, 48, 759-774.
[6] Marton, L.J. and Pegg, A.E. (1995) Polyamines as targets for therapeutic intervention. Annual Review of Pharma-cology and Toxicology, 35, 55-91.
[7] Bardocz, S., White, A., Grant, G., Brown, D.S., Duguid, T.G. and Pusztai, A. (1996) Uptake and bioavailability of dietary polyamines. Biochemical Society Transactions, 24, 226S.
[8] Soda, K., Kano, Y., Sakuragi, M., Takao, K., Lefor, A. and Konishi, F. (2009) Long-term oral polyamine intake increases blood polyamine concentrations. Journal Nu-trition Science and Vitaminology (Tokyo), 55, 361-366.
[9] Nishibori, N., Fujihara, S. and Akatuki, T. (2007) Amounts of polyamines in foods in Japan and intake by Japanese. Food Chemistry, 100, 491-497.
[10] Nishimura, K., Shiina, R., Kashiwagi, K. and Igarashi, K. (2006) Decrease in polyamines with aging and their in-gestion from food and drink. Journal of Biochemistry, 139, 81-90.
[11] Cipolla, B.G., Havouis, R. and Moulinoux, J.P. (2007) Polyamine contents in current foods: a basis for polyamine reduced diet and a study of its long term observance and tolerance in prostate carcinoma patients. Amino Acids, 33, 203-212.
[12] Bardócz, S., Grant, G., Brown, D.S., Ralph, A. and Pusz-tai, A. (1993) Polyamines in food—implications for growth and health. Journal of Nutrition Biochemistry, 4, 66-71.
[13] Cooper, R., Cutler, J., Desvigne-Nickens, P., Fortmann, S. P., Friedman, L., Havlik, R., Hogelin, G., Marler, J., McGovern, P., Morosco, G., Mosca, L., Pearson, T., Stamler, J., Stryer, D. and Thom, T. (2000) Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease pre-vention. Circulation, 102, 3137-3147.
[14] Kaplan, G.A. and Keil, J.E. (1993) Socioeconomic factors and cardiovascular disease: a review of the literature. Circulation, 88, 1973-1998.
[15] Rooks, R.N., Simonsick, E.M., Miles, T., Newman, A., Kritchevsky, S.B., Schulz, R. and Harris, T. (2002) The association of race and socioeconomic status with cardi-ovascular disease indicators among older adults in the health, aging, and body composition study. Journals of Gerontology, 57, S247-256.
[16] Janssen, F., Kunst, A.E. and Mackenbach, J.P. (2006) Association between gross domestic product throughout the life course and old-age mortality across birth cohorts: parallel analyses of seven European countries, 1950-1999. Social Science & Medicine, 63, 239-254.
[17] Tresserras, R., Canela, J., Alvarez, J., Sentis, J. and Sal-leras, L. (1992) Infant mortality, per capita income, and adult illiteracy: an ecological approach. American Journal of Public Health, 82, 435-438.
[18] Beckfield, J. (2004) Does income inequality harm health? New cross-national evidence. Journal of Health & Social Behavior, 45, 231-248.
[19] Binh, P.N.T., Soda, K. and Kawakami, M. (2010) Gross domestic product and dietary pattern among 49 Western countries with a focus on polyamine intake. Health, 2, in press.
[20] Bardocz, S., Duguid, T.J., Brown, D.S., Grant, G., Pusztai, A., White, A. and Ralph, A. (1995) The importance of dietary polyamines in cell regeneration and growth. British Journal of Nutrition, 73, 819-828.
[21] Zoumas-Morse, C., Rock, C.L., Quintana, E.L., Neuh-ouser, M.L., Gerner, E. W. and Meyskens, F.L. (2007) Development of a polyamine database for assessing die-tary intake. Journal of the American Dietetic Association, 107, 1024-1027.
[22] Soda, K. (2010) Polyamine intake, dietary pattern, and cardiovascular disease. Medical Hypotheses, 75, 299-301.
[23] Lefer, A.M. and Lefer, D.J. (1996) The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion. Cardiovasc Research, 32, 743- 751.
[24] Drexler, H., Zeiher, A.M., Meinzer, K. and Just, H. (1991) Correction of endothelial dysfunction in coronary micro-circulation of hypercholesterolaemic patients by L-arginine. Lancet, 338, 1546-1550.
[25] Cooke, J.P., Singer, A.H., Tsao, P., Zera, P., Rowan, R.A., and Billingham, M.E. (1992) Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. Journal of Clinical Investigation, 90, 1168-1172.

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