Supercritical Fluid Adsorption of Domperidone on Silica Aerogel


Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35and 45 and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.

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G. Caputo, "Supercritical Fluid Adsorption of Domperidone on Silica Aerogel," Advances in Chemical Engineering and Science, Vol. 3 No. 3, 2013, pp. 189-194. doi: 10.4236/aces.2013.33024.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] R. B. Parmar, A. H. Baria, H. M. Tank and S. D. Faldu, “Formulation and Evaluation of Domperidone Fast Dissolving Tablets,” International Journal of PharmTech Research, Vol. 1, No. 3, 2009, pp. 483-487.
[2] M. S. Nagarsenker, S. D. Garad and G. Ramprakash, “Design, Optimization and Evaluation of Domperidone Coevaporates,” Journal of Controlled Release, Vol. 63, No. 1-2, 2000, pp. 31-39. doi:10.1016/S0168-3659(99)00177-7
[3] S. Pinnamaneni, N. G. Das and S. K. Das, “Formulation Approaches for Orally Administered Poorly Soluble Drugs,” Pharmazie, Vol. 57, No. 5, 2002, pp. 291-300.
[4] J. C. Chaumeil, “Micronization: A Method of Improving the Bioavailability of Poorly Soluble Drugs,” Methods & Findings in Experimental & Clinical Pharmacology, Vol. 20, 1998, pp. 211-215.
[5] V. B. Patravale, A. A. Date and R. M. Kulkarni, “Nanosuspensions: A Promising Drug Delivery Strategy,” Journal of Pharmacy and Pharmacology, Vol. 56, No. 7, 2004, pp. 827-840. doi:10.1211/0022357023691
[6] P. York, U. B. Kompella and B. Y. Shekunov, “Supercritical Fluid Technlogy for Drug Development,” Marcel Dekker, New York, 2004. doi:10.1201/9780203021378
[7] E. Reverchon, G. Caputo, S. Correra and P. Cesti, “Synthesis of Titanium Hydroxide Nanoparticles in Supercritical Carbon Dioxide on the Pilot Scale,” The Journal of Supercritical Fluids, Vol. 26, No. 3, 2003, pp. 253-261. doi:10.1016/S0896-8446(02)00163-8
[8] S. Liparoti, R. Adami, G. Caputo and E. Reverchon, “Supercritical Assisted Atomization: PVP as Carrier for Drug with Poor Solubility in Water,” Journal of Chemistry, 2013, Article ID: 801069. doi:10.1155/2013/801069
[9] G. Caputo, S. Liparoti, R. Adami and E. Reverchon, “Use of Supercritical CO2 and N2 as Dissolved Gases for the Atomization of Ethanol and Water,” I&ECR, Vol. 51, No. 36, 2012, pp. 11803-11808.
[10] A. M. Hillery, A. W. Lloyd and J. Swarbrick, “Drug Delivery und Targeting,” Taylor & Francis, London, New York, 2001.
[11] I. Smirnova, S. Suttiruengwong and W. Arlt, “Feasibility Study of Hydrophilic and Hydrophobic Silica Aerogels as Drug Delivery Systems,” Journal of Non-Crystalline Solids, Vol. 350, 2004, pp. 54-60.
[12] I. Smirnova, S. Suttiruengwong, M. Seiler and W. Arlt, “Dissolution Rate Enhancement by Adsorption of Poorly Soluble Drugs on Hydrophylic Silica Aerogels,” Pharmaceutical Development and Technology, Informa Healthcare, Vol. 9, 2005, pp. 443-452.
[13] U. Guenther, I. Smirnova and R. H. H. Neubert, “Hydrophilic Silica Aerogel as Dermal Drug Delivery Systems-Dithranol as a Model Drug,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 69, 2008, pp. 935-942.
[14] I. Smirnova, J. Mamic and W. Arlt, “Adsorption of Drugs on Silica Aerogels,” Langmuir, Vol. 19, 2003, pp. 8521-8525.
[15] G. Caputo, M. Scognamiglio and I. De Marco, “Nimesulide Adsorbed on Silica Aerogel Using Spercritical Carbon Dioxide,” Chemical Engineering Research and Design, Vol. 90, No. 8, 2012, pp. 1082-1089. doi:10.1016/j.cherd.2011.11.011
[16] G. Caputo, I. De Marco and E. Reverchon, “Silica Aerogel—Metal Composites Produced by Supercritical Adsorption,” The Journal of Supercritical Fluids, Vol. 54, No. 2, 2010, pp. 243-249. doi:10.1016/j.supflu.2010.05.003
[17] G. Brunner, “Gas Extraction, Topics in Physical Chemistry,” Vol. 4, Steinkopff, Springer, New York, Darmstadt 1994, pp. 123-125.
[18] S. Brunauer, L. S. Deming, W. E. Deming and E. Teller, “On a Theory of the van der Waals Adsorption of Gases,” Journal of the American Chemical Society, Vol. 62, 1940, pp. 1723-1732.

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